TY  - JOUR
AU  - Lamana, Amalia
AU  - Balsa, Alejandro
AU  - Rueda, Blanca
AU  - Ortiz, Ana M
AU  - Nuño, Laura
AU  - Miranda-Carus, Maria Eugenia
AU  - Gonzalez-Escribano, Maria F
AU  - Lopez-Nevot, Miguel A
AU  - Pascual-Salcedo, Dora
AU  - Martin, Javier
AU  - González-Álvaro, Isidoro
PY  - 2012
DO  - 10.1371/journal.pone.0043661
UR  - http://hdl.handle.net/10668/1408
T2  - PloS one
AB  - BACKGROUNDThe number of copies of the HLA-DRB1 shared epitope, and the minor alleles of the STAT4 rs7574865 and the PTPN22 rs2476601 polymorphisms have all been linked with an increased risk of developing rheumatoid arthritis. In the present study, we...
LA  - en
PB  - Public Library of Science
KW  - STAT4 Transcription Factor
KW  - PTPN22 protein, human
KW  - Protein Tyrosine Phosphatase, Non-Receptor Type 22
KW  - HLA-DRB1 Chains
KW  - Anciano
KW  - Alelos
KW  - Artritis
KW  - Evaluación de la Discapacidad
KW  - Predisposición Genética a la Enfermedad
KW  - Genotipo
KW  - Mediana Edad
KW  - Polimorfismo de Nucleótido Simple
KW  - Factor de Transcripción STAT4
KW  - Índice de Severidad de la Enfermedad
KW  - Adulto
KW  - Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Aged
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Alleles
KW  - Medical Subject Headings::Diseases::Musculoskeletal Diseases::Joint Diseases::Arthritis
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Disability Evaluation
KW  - Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Susceptibility::Genetic Predisposition to Disease
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Check Tags::Male
KW  - Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism, Single Nucleotide
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intracellular Signaling Peptides and Proteins::Adaptor Proteins, Signal Transducing::STAT Transcription Factors::STAT4 Transcription Factor
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Health Surveys::Health Status Indicators::Severity of Illness Index
KW  - Medical Subject Headings::Named Groups::Persons::Age Groups::Adult
KW  - Medical Subject Headings::Check Tags::Female
KW  - Medical Subject Headings::Chemicals and Drugs::Biological Factors::Antigens::Antigens, Surface::Histocompatibility Antigens::HLA Antigens::HLA-D Antigens::HLA-DR Antigens::HLA-DR beta-Chains::HLA-DRB1 Chains
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Esterases::Phosphoric Monoester Hydrolases::Protein Tyrosine Phosphatases::Protein Tyrosine Phosphatases, Non-Receptor::Protein Tyrosine Phosphatase,...
TI  - The TT genotype of the STAT4 rs7574865 polymorphism is associated with high disease activity and disability in patients with early arthritis
TY  - research article
ER  -