TY  - JOUR
AU  - McKie, Elizabeth A
AU  - Reid, Juliet L
AU  - Mistry, Prafull C
AU  - DeWall, Stephen L
AU  - Abberley, Lee
AU  - Ambery, Philip D
AU  - Gil-Extremera, Blas
PY  - 2016
DO  - 10.1371/journal.pone.0150018
UR  - http://hdl.handle.net/10668/2454
T2  - PloS One
AB  - OBJECTIVEEvidence suggests that chronic subclinical inflammation plays an important role in the pathogenesis of type 2 diabetes (T2DM). Circulating levels of interleukin (IL)-18 appear to be associated with a number of micro- and macrovascular...
LA  - en
PB  - Public Library of Science
KW  - Anticuerpos monoclonales humanizados
KW  - Glucemia
KW  - Diabetes Mellitus tipo II
KW  - Farmacoterapia combinada
KW  - Humanos
KW  - Hipoglucemiantes
KW  - Interleucina-18
KW  - Metformina
KW  - Obesidad
KW  - Método con una ocultación
KW  - Resultado del tratamiento
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Antibodies, Monoclonal::Antibodies, Monoclonal, Humanized
KW  - Medical Subject Headings::Chemicals and Drugs::Carbohydrates::Monosaccharides::Hexoses::Glucose::Blood Glucose
KW  - Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus::Diabetes Mellitus, Type 2
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Drug Therapy, Combination
KW  - Medical Subject Headings::Check Tags::Female
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Hypoglycemic Agents
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Interleukins::Interleukin-18
KW  - Medical Subject Headings::Check Tags::Male
KW  - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amidines::Guanidines::Biguanides::Metformin
KW  - Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged
KW  - Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Research Design::Single-Blind Method
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Treatment Outcome
KW  - Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Aged
TI  - A Study to Investigate the Efficacy and Safety of an Anti-Interleukin-18 Monoclonal Antibody in the Treatment of Type 2 Diabetes Mellitus.
TY  - research article
ER  -