TY  - JOUR
AU  - González-Cano, Rafael
AU  - Ruiz-Cantero, M. Carmen
AU  - Santos-Caballero, Miriam
AU  - Gómez-Navas, Carlos
AU  - Tejada, Miguel Á.
AU  - Nieto, Francisco R.
PY  - 2021
DO  - 10.3390/toxins13070483
UR  - http://hdl.handle.net/10668/4156
T2  - Toxins
AB  - Tetrodotoxin (TTX) is a potent neurotoxin found mainly in puffer fish and other marine and terrestrial animals. TTX blocks voltage-gated sodium channels (VGSCs) which are typically classified as TTX-sensitive or TTX-resistant channels. VGSCs play a...
LA  - en
PB  - MDPI
KW  - Tetrodotoxin
KW  - TTX
KW  - Voltage-gated sodium channels
KW  - Neuropathic pain
KW  - Cancer pain
KW  - Hyperalgesia
KW  - Tetrodotoxina
KW  - Canales de sodio activados por voltaje
KW  - Neuralgia
KW  - Dolor en cáncer
KW  - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Peripheral Nervous System Agents::Sensory System Agents::Analgesics
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals
KW  - Medical Subject Headings::Anatomy::Nervous System::Ganglia::Ganglia, Sensory::Ganglia, Spinal
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Diseases::Nervous System Diseases::Neurologic Manifestations::Sensation Disorders::Somatosensory Disorders::Hyperalgesia
KW  - Medical Subject Headings::Diseases::Neoplasms
KW  - Medical Subject Headings::Diseases::Nervous System Diseases::Neurologic Manifestations::Pain::Neuralgia
KW  - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Toxic Actions::Noxae::Neurotoxins
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Pain Management
KW  - Medical Subject Headings::Chemicals and Drugs::Pharmaceutical Preparations
KW  - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Membrane Transport Modulators::Sodium Channel Blockers
KW  - Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Quinazolines::Tetrodotoxin
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Nerve Tissue Proteins::Voltage-Gated Sodium Channels
KW  - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Up-Regulation
KW  - Medical Subject Headings::Anatomy::Nervous System::Neurons::Neurons, Afferent::Sensory Receptor Cells
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Fishes::Tetraodontiformes
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation
TI  - Tetrodotoxin, a Potential Drug for Neuropathic and Cancer Pain Relief?
TY  - review article
ER  -