RT Journal Article
T1 New insights into the role of the immune microenvironment in breast carcinoma.
A1 de la Cruz-Merino, Luis
A1 Barco-Sánchez, Antonio
A1 Henao Carrasco, Fernando
A1 Nogales Fernández, Esteban
A1 Vallejo Benítez, Ana
A1 Brugal Molina, Javier
A1 Martínez Peinado, Antonio
A1 Grueso López, Ana
A1 Ruiz Borrego, Manuel
A1 Codes Manuel de Villena, Manuel
A1 Sánchez-Margalet, Víctor
A1 Nieto-García, Adoración
A1 Alba Conejo, Emilio
A1 Casares Lagar, Noelia
A1 Ibáñez Martínez, José
K1 Neoplasias de la mama
K1 Carcinoma
K1 Tolerancia inmunológica
K1 Linfocitos infiltrantes de tumor
K1 Células mieloides
AB Recently, immune edition has been recognized as a new hallmark of cancer. In this respect, some clinical trials in breast cancer have reported imppressive outcomes related to laboratory immune findings, especially in the neoadjuvant and metastatic setting. Infiltration by tumor infiltrating lymphocytes (TIL) and their subtypes, tumor-associated macrophages (TAM) and myeloid-derived suppressive cells (MDSC) seem bona fide prognostic and even predictive biomarkers, that will eventually be incorporated into diagnostic and therapeutic algorithms of breast cancer. In addition, the complex interaction of costimulatory and coinhibitory molecules on the immune synapse and the different signals that they may exert represent another exciting field to explore. In this review we try to summarize and elucidate these new concepts and knowledge from a translational perspective focusing on breast cancer, paying special attention to those aspects that might have more significance in clinical practice and could be useful to design successful therapeutic strategies in the future.
PB Hindawi Publishing Corporation
SN 1740-2522
YR 2013
FD 2013
LK http://hdl.handle.net/10668/2094
UL http://hdl.handle.net/10668/2094
LA en
NO de la Cruz-Merino L, Barco-Sánchez A, Henao Carrasco F, Nogales Fernández E, Vallejo Benítez A, Brugal Molina J, et al. New insights into the role of the immune microenvironment in breast carcinoma. Clin. Dev. Immunol.2013;2013:785317
NO Journal Article; Review;
DS RISalud
RD Apr 8, 2025