RT Journal Article
T1 Insights on the health benefits of the bioactive compounds of coffee silverskin extract
A1 Fernandez-Gomez, Beatriz
A1 Lezama, Adriana
A1 Amigo-Benavent, Miryam
A1 Ullate, Monica
A1 Herrero, Miguel
A1 Angeles Martin, Maria
A1 Dolores Mesa, Maria
A1 Dolores del Castillo, Maria
K1 Coffee silverskin
K1 Chlorogenic acid
K1 Bioaccessibility
K1 Metabolism
K1 Type 2 diabetes
K1 In-vitro
K1 Chlorogenic acid
K1 Antioxidant capacity
K1 Oxidative stress
K1 Gastrointestinal digestion
K1 Caffeine
K1 Streptozotocin
K1 Bioaccessibility
K1 Cells
K1 Rats
AB The bioaccessibility of chlorogenic acid (CGA) and caffeine in coffee silverskin extracts (CSE) and the contribution of these substances to the prophylactic effect of CSE on the pathogenesis of diabetes have not been reported. This study aimed to evaluate the bioaccessibility, bioavailability and bioactivity of CGA and caffeine alone and in CSE in the pancreas of rats treated with streptozotocin-nicotinamide (type 2 diabetes model). Metabolism of CGA and caffeine started in the gastrointestinal tract due to changes of pH taking place during digestion. Their metabolites protected pancreatic cells against the risk of diabetes. This is the first in vivo study to demonstrate a specific chemo-protective effect of CSE in pancreatic tissue, and this effect may be associated with its antioxidant capacity. Daily administration of CSE, CGA or caffeine 35 d previous to the induction of diabetes significantly reduced (p < 0.05) pancreatic oxidative stress and protein damage.
PB Elsevier BV
SN 1756-4646
YR 2016
FD 2016-07-04
LK http://hdl.handle.net/10668/18815
UL http://hdl.handle.net/10668/18815
LA en
NO Beatriz Fernandez-Gomez, Adriana Lezama, Miryam Amigo-Benavent, Mónica Ullate, Miguel Herrero, María Ángeles Martín, et al. Insights on the health benefits of the bioactive compounds of coffee silverskin extract, Journal of Functional Foods, Volume 25, 2016, Pages 197-207,
DS RISalud
RD Apr 19, 2025