RT Journal Article
T1 Differences in clinical features and mortality in very old unvaccinated patients (≥ 80 years) hospitalized with COVID-19 during the first and successive waves from the multicenter SEMI-COVID-19 Registry (Spain).
A1 Ramos-Rincon, Jose-Manuel
A1 Cobos-Palacios, Lidia
A1 Lopez-Sampalo, Almudena
A1 Ricci, Michele
A1 Rubio-Rivas, Manel
A1 Nuñez-Rodriguez, Maria-Victoria
A1 Miranda-Godoy, Rodrigo
A1 Garcia-Leoni, Maria-Eugenia
A1 Fernandez-Madera-Martinez, Rosa
A1 Garcia-Garcia, Gema-Maria
A1 Beato-Perez, Jose-Luis
A1 Monge-Monge, Daniel
A1 Asin-Samper, Uxua
A1 Bustamante-Vega, Marta
A1 Rabago-Lorite, Isabel
A1 Freire-Castro, Santiago-Jesus
A1 Miramontes-Gonzalez, Jose-Pablo
A1 Magallanes-Gamboa, Jeffrey-Oskar
A1 Alcala-Pedrajas, Jose-Nicolas
A1 Garcia-Gomez, Miriam
A1 Cano-Llorente, Veronica
A1 Carrasco-Sanchez, Francisco-Javier
A1 Martinez-Carrilero, Jesus
A1 Anton-Santos, Juan-Miguel
A1 Gomez-Huelgas, Ricardo
A1 SEMI-COVID-19 Network, 
K1 80 and over
K1 Aged
K1 COVID-19
K1 Comorbidity
K1 Complications
K1 Epidemiology
K1 Morbidity
K1 Mortality
K1 SARS-CoV-2
K1 Spain
K1 Área Sanitaria Norte de Córdoba
AB Old age is one of the most important risk factors for severe COVID-19. Few studies have analyzed changes in the clinical characteristics and prognosis of COVID-19 among older adults before the availability of vaccines. This work analyzes differences in clinical features and mortality in unvaccinated very old adults during the first and successive COVID-19 waves in Spain. This nationwide, multicenter, retrospective cohort study analyzes unvaccinated patients ≥ 80 years hospitalized for COVID-19 in 150 Spanish hospitals (SEMI-COVID-19 Registry). Patients were classified according to whether they were admitted in the first wave (March 1-June 30, 2020) or successive waves (July 1-December 31, 2020). The endpoint was all-cause in-hospital mortality, expressed as the case fatality rate (CFR). Of the 21,461 patients hospitalized with COVID-19, 5,953 (27.7%) were ≥ 80 years (mean age [IQR]: 85.6 [82.3-89.2] years). Of them, 4,545 (76.3%) were admitted during the first wave and 1,408 (23.7%) during successive waves. Patients hospitalized in successive waves were older, had a greater Charlson Comorbidity Index and dependency, less cough and fever, and met fewer severity criteria at admission (qSOFA index, PO2/FiO2 ratio, inflammatory parameters). Significant differences were observed in treatments used in the first (greater use of antimalarials, lopinavir, and macrolides) and successive waves (greater use of corticosteroids, tocilizumab and remdesivir). In-hospital complications, especially acute respiratory distress syndrome and pneumonia, were less frequent in patients hospitalized in successive waves, except for heart failure. The CFR was significantly higher in the first wave (44.1% vs. 33.3%; -10.8%; p  Mortality declined significantly between the first and successive waves in very old unvaccinated patients hospitalized with COVID-19 in Spain. This decline could be explained by a greater availability of hospital resources and more effective treatments as the pandemic progressed, although other factors such as changes in SARS-CoV-2 virulence cannot be ruled out.
PB BioMed Central
YR 2022
FD 2022-06-30
LK http://hdl.handle.net/10668/20268
UL http://hdl.handle.net/10668/20268
LA en
NO Ramos-Rincon JM, Cobos-Palacios L, López-Sampalo A, Ricci M, Rubio-Rivas M, Nuñez-Rodriguez MV, et al. Differences in clinical features and mortality in very old unvaccinated patients (≥ 80 years) hospitalized with COVID-19 during the first and successive waves from the multicenter SEMI-COVID-19 Registry (Spain). BMC Geriatr. 2022 Jun 30;22(1):546
DS RISalud
RD Apr 11, 2025