RT Journal Article
T1 Current Knowledge about the Effect of Nutritional Status, Supplemented Nutrition Diet, and Gut Microbiota on Hepatic Ischemia-Reperfusion and Regeneration in Liver Surgery
A1 Cornide-Petronio, María Eugenia
A1 Álvarez-Mercado, Ana Isabel
A1 Jiménez-Castro, Mónica B.
A1 Peralta, Carmen
K1 Ischemia-reperfusion injury
K1 Nutritional status
K1 Supplemented nutrition
K1 Gut microbiota
K1 Partial hepatectomy
K1 Liver transplantation
K1 Daño por reperfusión
K1 Estado nutricional
K1 Suplementos dietéticos
K1 Microbioma gastrointestinal
K1 Hepatectomía
K1 Trasplante de hígado
AB Ischemia-reperfusion (I/R) injury is an unresolved problem in liver resection and transplantation. The preexisting nutritional status related to the gut microbial profile might contribute to primary non-function after surgery. Clinical studies evaluating artificial nutrition in liver resection are limited. The optimal nutritional regimen to support regeneration has not yet been exactly defined. However, overnutrition and specific diet factors are crucial for the nonalcoholic or nonalcoholic steatohepatitis liver diseases. Gut-derived microbial products and the activation of innate immunity system and inflammatory response, leading to exacerbation of I/R injury or impaired regeneration after resection. This review summarizes the role of starvation, supplemented nutrition diet, nutritional status, and alterations in microbiota on hepatic I/R and regeneration. We discuss the most updated effects of nutritional interventions, their ability to alter microbiota, some of the controversies, and the suitability of these interventions as potential therapeutic strategies in hepatic resection and transplantation, overall highlighting the relevance of considering the extended criteria liver grafts in the translational liver surgery.
PB MDPI
YR 2020
FD 2020-01-21
LK http://hdl.handle.net/10668/3651
UL http://hdl.handle.net/10668/3651
LA en
NO Cornide-Petronio ME, Álvarez-Mercado AI, Jiménez-Castro MB, Peralta C. Current Knowledge about the Effect of Nutritional Status, Supplemented Nutrition Diet, and Gut Microbiota on Hepatic Ischemia-Reperfusion and Regeneration in Liver Surgery. Nutrients. 2020 Jan 21;12(2):284
DS RISalud
RD Apr 5, 2025