TY - JOUR AU - Cippitelli, Andrea AU - Astarita, Giuseppe AU - Duranti, Andrea AU - Caprioli, Giovanni AU - Ubaldi, Massimo AU - Stopponi, Serena AU - Kallupi, Marsida AU - Sagratini, Gianni AU - Rodríguez de Fonseca, Fernando AU - Piomelli, Daniele AU - Ciccocioppo, Roberto PY - 2011 DO - 10.1371/journal.pone.0028142 UR - http://hdl.handle.net/10668/704 T2 - PloS ONE AB - Evidence shows that the endocannabinoid system modulates the addictive properties of nicotine. In the present study, we hypothesized that spontaneous withdrawal resulting from removal of chronically implanted transdermal nicotine patches is regulated... LA - en PB - Public Library of Science KW - Enfermedad aguda KW - Amidohidrolasas KW - Animales KW - Ansiedad KW - Ácidos araquidónicos KW - Benzamidas KW - Encéfalo KW - Carbamatos KW - Cotinina KW - Endocanabinoides KW - Glicéridos KW - Implantes experimentales KW - Locomoción KW - Masculino KW - Aprendizaje por laberinto KW - Nicotina KW - Alcamidas poliinsaturadas KW - Ratas KW - Síndrome de abstinencia a sustancias KW - Productos para dejar de fumar tabaco KW - Aumento de peso KW - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Amidohydrolases KW - Medical Subject Headings::Organisms::Eukaryota::Animals KW - Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Emotions::Anxiety KW - Medical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids, Unsaturated::Arachidonic Acids KW - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amides::Benzamides KW - Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain KW - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Carboxylic Acids::Acids, Acyclic::Carbamates KW - Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Pyrrolidines::Pyrrolidinones::Cotinine KW - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Neurotransmitter Agents::Endocannabinoids KW - Medical Subject Headings::Chemicals and Drugs::Lipids::Glycerides KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Equipment and Supplies::Prostheses and Implants::Implants, Experimental KW - Medical Subject Headings::Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Musculoskeletal Physiological Processes::Movement::Locomotion KW - Medical Subject Headings::Check Tags::Male KW - Medical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Learning::Maze Learning KW - Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Alkaloids::Solanaceous Alkaloids::Nicotine KW - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amides::Polyunsaturated Alkamides KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats::Rats, Wistar KW - Medical Subject Headings::Diseases::Substance-Related Disorders::Substance Withdrawal Syndrome KW - Medical Subject Headings::Technology, Industry, Agriculture::Technology, Industry, and Agriculture::Manufactured Materials::Tobacco Use Cessation Products KW - Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::Growth and Development::Growth::Body Size::Body Weight::Body Weight Changes::Weight Gain KW - Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Acute Disease TI - Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition. TY - research article ER -