TY - JOUR AU - Navas, Lola E. AU - Carnero, Amancio PY - 2021 DO - 10.1038/s41392-020-00354-w UR - http://hdl.handle.net/10668/3566 T2 - Signal Transduction and Targeted Therapy AB - NAD+ was discovered during yeast fermentation, and since its discovery, its important roles in redox metabolism, aging, and longevity, the immune system and DNA repair have been highlighted. A deregulation of the NAD+ levels has been associated with... LA - en PB - Springer Nature KW - Cancer stem cells KW - Molecular medicine KW - Cancer metabolism KW - Cancer therapy KW - Células madre neoplásicas KW - Medicina molecular KW - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Chemical Processes::Physicochemical Processes::Oxidation-Reduction KW - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Cycle::Cell Division::Cytokinesis KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Damage KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans KW - Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Purines::Purine Nucleotides::Adenine Nucleotides::NAD KW - Medical Subject Headings::Diseases::Neoplasms KW - Medical Subject Headings::Anatomy::Hemic and Immune Systems::Immune System KW - Medical Subject Headings::Anatomy::Cells::Stem Cells::Neoplastic Stem Cells KW - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Glycosyltransferases::Pentosyltransferases::Nicotinamide Phosphoribosyltransferase TI - NAD+ metabolism, stemness, the immune response, and cancer TY - review article ER -