RT Journal Article
T1 Prognostic Value of Variations in Serum Biomarkers and Prognostic Scores Values Between Admission and Second Day in Intensive Care Unit Septic Patients.
A1 Rios-Toro, Juan Jesus
A1 Pola-Gallego de Guzman, Maria Dolores
A1 Guerrero-Marin, Maria
A1 Rodriguez-Rubio, David
A1 Ruiz-Garcia, Maria Isabel
A1 Aguilar-Alonso, Eduardo
A1 Rivera-Fernandez, Ricardo
K1 acute physiology and chronic health evaluation ii
K1 c-reactive protein
K1 intensive care
K1 procalcitonin
K1 sepsis
K1 sepsis-related organ failure assessment
AB Objective To determinate the prognostic value of procalcitonin (PCT) and C-reactive protein (CRP) changes during the first two days of admission to the ICU with sepsis and/or septic shock, and to compare it with changes in Acute Physiology And Chronic Health Evaluation II (APACHE-II) and Sepsis-related Organ Failure Assessment (SOFA) prognostic scores. Methods A single-center prospective observational study was performed. Fifty consecutive patients admitted to the ICU, diagnosed of severe sepsis/septic shock were included. We considered risk factors for infection: diabetes mellitus, chronic obstructive pulmonary disease (COPD), previous antibiotic treatment, central intravascular catheter, bladder catheter, active neoplasia. Results Median aged 67(52-75) years with median APACHE-II 19(14-25) points and SOFA scores 7(5-11) points on admission, and 28-day mortality of 42%. When we studied the relationship between mortality and the changes between the day of admission and the second day of the variables studied, we found that APACHE-II (p = 0.001) and SOFA (p = 0.002) between admission and second day raised significantly in no survivors, with no significant changes in CRP and PCT. Multivariate analysis showed that mortality was significantly associated to changes in SOFA score (odds ratio [OR], 2.13; 95% confidence interval [CI], 1.18-3.86) and to the presence of one or more risk factors for infection (OR, 6.01; 95% CI, 1.01-35.78) but not with PCT changes. Mortality was also related to the variations between the day of admission and the fifth day on APACHE-II (p = 0.002), SOFA (p
SN 2168-8184
YR 2021
FD 2021-07-19
LK https://hdl.handle.net/10668/25315
UL https://hdl.handle.net/10668/25315
LA en
DS RISalud
RD Apr 5, 2025