RT Journal Article
T1 Analysis of shared heritability in common disorders of the brain.
A1 Anttila, Verneri
A1 Bulik-Sullivan, Brendan
A1 Finucane, Hilary K
A1 Walters, Raymond K
A1 Bras, Jose
A1 Duncan, Laramie
A1 Escott-Price, Valentina
A1 Falcone, Guido J
A1 Gormley, Padhraig
A1 Malik, Rainer
A1 Patsopoulos, Nikolaos A
A1 Ripke, Stephan
A1 Wei, Zhi
A1 Yu, Dongmei
A1 Lee, Phil H
A1 Turley, Patrick
A1 Grenier-Boley, Benjamin
A1 Chouraki, Vincent
A1 Kamatani, Yoichiro
A1 Berr, Claudine
A1 Letenneur, Luc
A1 Hannequin, Didier
A1 Amouyel, Philippe
A1 Boland, Anne
A1 Deleuze, Jean-François
A1 Duron, Emmanuelle
A1 Vardarajan, Badri N
A1 Reitz, Christiane
A1 Goate, Alison M
A1 Huentelman, Matthew J
A1 Kamboh, M Ilyas
A1 Larson, Eric B
A1 Rogaeva, Ekaterina
A1 St George-Hyslop, Peter
A1 Hakonarson, Hakon
A1 Kukull, Walter A
A1 Farrer, Lindsay A
A1 Barnes, Lisa L
A1 Beach, Thomas G
A1 Demirci, F Yesim
A1 Head, Elizabeth
A1 Hulette, Christine M
A1 Jicha, Gregory A
A1 Kauwe, John S K
A1 Kaye, Jeffrey A
A1 Leverenz, James B
A1 Levey, Allan I
A1 Lieberman, Andrew P
A1 Pankratz, Vernon S
A1 Poon, Wayne W
A1 Quinn, Joseph F
A1 Saykin, Andrew J
A1 Schneider, Lon S
A1 Smith, Amanda G
A1 Sonnen, Joshua A
A1 Stern, Robert A
A1 Van Deerlin, Vivianna M
A1 Van Eldik, Linda J
A1 Harold, Denise
A1 Russo, Giancarlo
A1 Rubinsztein, David C
A1 Bayer, Anthony
A1 Tsolaki, Magda
A1 Proitsi, Petra
A1 Fox, Nick C
A1 Hampel, Harald
A1 Owen, Michael J
A1 Mead, Simon
A1 Passmore, Peter
A1 Morgan, Kevin
A1 Nöthen, Markus M
A1 Rossor, Martin
A1 Lupton, Michelle K
A1 Hoffmann, Per
A1 Kornhuber, Johannes
A1 Lawlor, Brian
A1 McQuillin, Andrew
A1 Al-Chalabi, Ammar
A1 Bis, Joshua C
A1 Ruiz, Agustin
A1 Boada, Mercè
A1 Seshadri, Sudha
A1 Beiser, Alexa
A1 Rice, Kenneth
A1 van der Lee, Sven J
A1 De Jager, Philip L
A1 Geschwind, Daniel H
A1 Riemenschneider, Matthias
A1 Riedel-Heller, Steffi
A1 Rotter, Jerome I
A1 Ransmayr, Gerhard
A1 Hyman, Bradley T
A1 Cruchaga, Carlos
A1 Alegret, Montserrat
A1 Winsvold, Bendik
A1 Palta, Priit
A1 Farh, Kai-How
A1 Cuenca-Leon, Ester
A1 Furlotte, Nicholas
A1 Kurth, Tobias
A1 Ligthart, Lannie
A1 Terwindt, Gisela M
A1 Freilinger, Tobias
A1 Ran, Caroline
A1 Gordon, Scott D
A1 Borck, Guntram
A1 Adams, Hieab H H
A1 Lehtimäki, Terho
A1 Wedenoja, Juho
A1 Buring, Julie E
A1 Schürks, Markus
A1 Hrafnsdottir, Maria
A1 Hottenga, Jouke-Jan
A1 Penninx, Brenda
A1 Artto, Ville
A1 Kaunisto, Mari
A1 Vepsäläinen, Salli
A1 Martin, Nicholas G
A1 Montgomery, Grant W
A1 Kurki, Mitja I
A1 Hämäläinen, Eija
A1 Huang, Hailiang
A1 Huang, Jie
A1 Sandor, Cynthia
A1 Webber, Caleb
A1 Muller-Myhsok, Bertram
A1 Schreiber, Stefan
A1 Salomaa, Veikko
A1 Loehrer, Elizabeth
A1 Göbel, Hartmut
A1 Macaya, Alfons
A1 Pozo-Rosich, Patricia
A1 Hansen, Thomas
A1 Werge, Thomas
A1 Kaprio, Jaakko
A1 Metspalu, Andres
A1 Kubisch, Christian
A1 Ferrari, Michel D
A1 Belin, Andrea C
A1 van den Maagdenberg, Arn M J M
A1 Zwart, John-Anker
A1 Boomsma, Dorret
A1 Eriksson, Nicholas
A1 Olesen, Jes
A1 Chasman, Daniel I
A1 Nyholt, Dale R
A1 Avbersek, Andreja
A1 Baum, Larry
A1 Berkovic, Samuel
A1 Bradfield, Jonathan
A1 Buono, Russell J
A1 Catarino, Claudia B
A1 Cossette, Patrick
A1 De Jonghe, Peter
A1 Depondt, Chantal
A1 Dlugos, Dennis
A1 Ferraro, Thomas N
A1 French, Jacqueline
A1 Hjalgrim, Helle
A1 Jamnadas-Khoda, Jennifer
A1 Kälviäinen, Reetta
A1 Kunz, Wolfram S
A1 Lerche, Holger
A1 Leu, Costin
A1 Lindhout, Dick
A1 Lo, Warren
A1 Lowenstein, Daniel
A1 McCormack, Mark
A1 Møller, Rikke S
A1 Molloy, Anne
A1 Ng, Ping-Wing
A1 Oliver, Karen
A1 Privitera, Michael
A1 Radtke, Rodney
A1 Ruppert, Ann-Kathrin
A1 Sander, Thomas
A1 Schachter, Steven
A1 Schankin, Christoph
A1 Scheffer, Ingrid
A1 Schoch, Susanne
A1 Sisodiya, Sanjay M
A1 Smith, Philip
A1 Sperling, Michael
A1 Striano, Pasquale
A1 Surges, Rainer
A1 Thomas, G Neil
A1 Visscher, Frank
A1 Whelan, Christopher D
A1 Zara, Federico
A1 Heinzen, Erin L
A1 Marson, Anthony
A1 Becker, Felicitas
A1 Stroink, Hans
A1 Zimprich, Fritz
A1 Gasser, Thomas
A1 Gibbs, Raphael
A1 Heutink, Peter
A1 Martinez, Maria
A1 Morris, Huw R
A1 Sharma, Manu
A1 Ryten, Mina
A1 Mok, Kin Y
A1 Pulit, Sara
A1 Bevan, Steve
A1 Holliday, Elizabeth
A1 Attia, John
A1 Battey, Thomas
A1 Boncoraglio, Giorgio
A1 Thijs, Vincent
A1 Chen, Wei-Min
A1 Mitchell, Braxton
A1 Rothwell, Peter
A1 Sharma, Pankaj
A1 Sudlow, Cathie
A1 Vicente, Astrid
A1 Markus, Hugh
A1 Kourkoulis, Christina
A1 Pera, Joana
A1 Raffeld, Miriam
A1 Silliman, Scott
A1 Boraska Perica, Vesna
A1 Thornton, Laura M
A1 Huckins, Laura M
A1 William Rayner, N
A1 Lewis, Cathryn M
A1 Gratacos, Monica
A1 Rybakowski, Filip
A1 Keski-Rahkonen, Anna
A1 Raevuori, Anu
A1 Hudson, James I
A1 Reichborn-Kjennerud, Ted
A1 Monteleone, Palmiero
A1 Karwautz, Andreas
A1 Mannik, Katrin
A1 Baker, Jessica H
A1 O'Toole, Julie K
A1 Trace, Sara E
A1 Davis, Oliver S P
A1 Helder, Sietske G
A1 Ehrlich, Stefan
A1 Herpertz-Dahlmann, Beate
A1 Danner, Unna N
A1 van Elburg, Annemarie A
A1 Clementi, Maurizio
A1 Forzan, Monica
A1 Docampo, Elisa
A1 Lissowska, Jolanta
A1 Hauser, Joanna
A1 Tortorella, Alfonso
A1 Maj, Mario
A1 Gonidakis, Fragiskos
A1 Tziouvas, Konstantinos
A1 Papezova, Hana
A1 Yilmaz, Zeynep
A1 Wagner, Gudrun
A1 Cohen-Woods, Sarah
A1 Herms, Stefan
A1 Julià, Antonio
A1 Rabionet, Raquel
A1 Dick, Danielle M
A1 Ripatti, Samuli
A1 Andreassen, Ole A
A1 Espeseth, Thomas
A1 Lundervold, Astri J
A1 Steen, Vidar M
A1 Pinto, Dalila
A1 Scherer, Stephen W
A1 Aschauer, Harald
A1 Schosser, Alexandra
A1 Alfredsson, Lars
A1 Padyukov, Leonid
A1 Halmi, Katherine A
A1 Mitchell, James
A1 Strober, Michael
A1 Bergen, Andrew W
A1 Kaye, Walter
A1 Szatkiewicz, Jin Peng
A1 Cormand, Bru
A1 Ramos-Quiroga, Josep Antoni
A1 Sánchez-Mora, Cristina
A1 Ribasés, Marta
A1 Casas, Miguel
A1 Hervas, Amaia
A1 Arranz, Maria Jesús
A1 Haavik, Jan
A1 Zayats, Tetyana
A1 Johansson, Stefan
A1 Williams, Nigel
A1 Dempfle, Astrid
A1 Rothenberger, Aribert
A1 Kuntsi, Jonna
A1 Oades, Robert D
A1 Banaschewski, Tobias
A1 Franke, Barbara
A1 Buitelaar, Jan K
A1 Arias Vasquez, Alejandro
A1 Doyle, Alysa E
A1 Reif, Andreas
A1 Lesch, Klaus-Peter
A1 Freitag, Christine
A1 Rivero, Olga
A1 Palmason, Haukur
A1 Romanos, Marcel
A1 Langley, Kate
A1 Rietschel, Marcella
A1 Witt, Stephanie H
A1 Dalsgaard, Soeren
A1 Børglum, Anders D
A1 Waldman, Irwin
A1 Wilmot, Beth
A1 Molly, Nikolas
A1 Bau, Claiton H D
A1 Crosbie, Jennifer
A1 Schachar, Russell
A1 Loo, Sandra K
A1 McGough, James J
A1 Grevet, Eugenio H
A1 Medland, Sarah E
A1 Robinson, Elise
A1 Weiss, Lauren A
A1 Bacchelli, Elena
A1 Bailey, Anthony
A1 Bal, Vanessa
A1 Battaglia, Agatino
A1 Betancur, Catalina
A1 Bolton, Patrick
A1 Cantor, Rita
A1 Celestino-Soper, Patrícia
A1 Dawson, Geraldine
A1 De Rubeis, Silvia
A1 Duque, Frederico
A1 Green, Andrew
A1 Klauck, Sabine M
A1 Leboyer, Marion
A1 Levitt, Pat
A1 Maestrini, Elena
A1 Mane, Shrikant
A1 De-Luca, Daniel Moreno-
A1 Parr, Jeremy
A1 Regan, Regina
A1 Reichenberg, Abraham
A1 Sandin, Sven
A1 Vorstman, Jacob
A1 Wassink, Thomas
A1 Wijsman, Ellen
A1 Cook, Edwin
A1 Santangelo, Susan
A1 Delorme, Richard
A1 Rogé, Bernadette
A1 Magalhaes, Tiago
A1 Arking, Dan
A1 Schulze, Thomas G
A1 Thompson, Robert C
A1 Strohmaier, Jana
A1 Matthews, Keith
A1 Melle, Ingrid
A1 Morris, Derek
A1 Blackwood, Douglas
A1 McIntosh, Andrew
A1 Bergen, Sarah E
A1 Schalling, Martin
A1 Jamain, Stephane
A1 Maaser, Anna
A1 Fischer, Sascha B
A1 Reinbold, Celine S
A1 Fullerton, Janice M
A1 Guzman-Parra, Jose
A1 Mayoral, Fermin
A1 Schofield, Peter R
A1 Cichon, Sven
A1 Mühleisen, Thomas W
A1 Degenhardt, Franziska
A1 Schumacher, Johannes
A1 Bauer, Michael
A1 Mitchell, Philip B
A1 Gershon, Elliot S
A1 Rice, John
A1 Potash, James B
A1 Zandi, Peter P
A1 Craddock, Nick
A1 Ferrier, I Nicol
A1 Alda, Martin
A1 Rouleau, Guy A
A1 Turecki, Gustavo
A1 Ophoff, Roel
A1 Pato, Carlos
A1 Anjorin, Adebayo
A1 Stahl, Eli
A1 Leber, Markus
A1 Czerski, Piotr M
A1 Cruceanu, Cristiana
A1 Jones, Ian R
A1 Posthuma, Danielle
A1 Andlauer, Till F M
A1 Forstner, Andreas J
A1 Streit, Fabian
A1 Baune, Bernhard T
A1 Air, Tracy
A1 Sinnamon, Grant
A1 Wray, Naomi R
A1 MacIntyre, Donald J
A1 Porteous, David
A1 Homuth, Georg
A1 Rivera, Margarita
A1 Grove, Jakob
A1 Middeldorp, Christel M
A1 Hickie, Ian
A1 Pergadia, Michele
A1 Mehta, Divya
A1 Smit, Johannes H
A1 Jansen, Rick
A1 de Geus, Eco
A1 Dunn, Erin
A1 Li, Qingqin S
A1 Nauck, Matthias
A1 Schoevers, Robert A
A1 Beekman, Aartjan Tf
A1 Knowles, James A
A1 Viktorin, Alexander
A1 Arnold, Paul
A1 Barr, Cathy L
A1 Bedoya-Berrio, Gabriel
A1 Bienvenu, O Joseph
A1 Brentani, Helena
A1 Burton, Christie
A1 Camarena, Beatriz
A1 Cappi, Carolina
A1 Cath, Danielle
A1 Cavallini, Maria
A1 Cusi, Daniele
A1 Darrow, Sabrina
A1 Denys, Damiaan
A1 Derks, Eske M
A1 Dietrich, Andrea
A1 Fernandez, Thomas
A1 Figee, Martijn
A1 Freimer, Nelson
A1 Gerber, Gloria
A1 Grados, Marco
A1 Greenberg, Erica
A1 Hanna, Gregory L
A1 Hartmann, Andreas
A1 Hirschtritt, Matthew E
A1 Hoekstra, Pieter J
A1 Huang, Alden
A1 Huyser, Chaim
A1 Illmann, Cornelia
A1 Jenike, Michael
A1 Kuperman, Samuel
A1 Leventhal, Bennett
A1 Lochner, Christine
A1 Lyon, Gholson J
A1 Macciardi, Fabio
A1 Madruga-Garrido, Marcos
A1 Malaty, Irene A
A1 Maras, Athanasios
A1 McGrath, Lauren
A1 Miguel, Euripedes C
A1 Mir, Pablo
A1 Nestadt, Gerald
A1 Nicolini, Humberto
A1 Okun, Michael S
A1 Pakstis, Andrew
A1 Paschou, Peristera
A1 Piacentini, John
A1 Pittenger, Christopher
A1 Plessen, Kerstin
A1 Ramensky, Vasily
A1 Ramos, Eliana M
A1 Reus, Victor
A1 Richter, Margaret A
A1 Riddle, Mark A
A1 Robertson, Mary M
A1 Roessner, Veit
A1 Rosário, Maria
A1 Samuels, Jack F
A1 Sandor, Paul
A1 Stein, Dan J
A1 Tsetsos, Fotis
A1 Van Nieuwerburgh, Filip
A1 Weatherall, Sarah
A1 Wendland, Jens R
A1 Wolanczyk, Tomasz
A1 Worbe, Yulia
A1 Zai, Gwyneth
A1 Goes, Fernando S
A1 McLaughlin, Nicole
A1 Nestadt, Paul S
A1 Grabe, Hans-Jorgen
A1 Depienne, Christel
A1 Konkashbaev, Anuar
A1 Lanzagorta, Nuria
A1 Valencia-Duarte, Ana
A1 Bramon, Elvira
A1 Buccola, Nancy
A1 Cahn, Wiepke
A1 Cairns, Murray
A1 Chong, Siow A
A1 Cohen, David
A1 Crespo-Facorro, Benedicto
A1 Crowley, James
A1 Davidson, Michael
A1 DeLisi, Lynn
A1 Dinan, Timothy
A1 Donohoe, Gary
A1 Drapeau, Elodie
A1 Duan, Jubao
A1 Haan, Lieuwe
A1 Hougaard, David
A1 Karachanak-Yankova, Sena
A1 Khrunin, Andrey
A1 Klovins, Janis
A1 Kučinskas, Vaidutis
A1 Lee Chee Keong, Jimmy
A1 Limborska, Svetlana
A1 Loughland, Carmel
A1 Lönnqvist, Jouko
A1 Maher, Brion
A1 Mattheisen, Manuel
A1 McDonald, Colm
A1 Murphy, Kieran C
A1 Nenadic, Igor
A1 van Os, Jim
A1 Pantelis, Christos
A1 Pato, Michele
A1 Petryshen, Tracey
A1 Quested, Digby
A1 Roussos, Panos
A1 Sanders, Alan R
A1 Schall, Ulrich
A1 Schwab, Sibylle G
A1 Sim, Kang
A1 So, Hon-Cheong
A1 Stögmann, Elisabeth
A1 Subramaniam, Mythily
A1 Toncheva, Draga
A1 Waddington, John
A1 Walters, James
A1 Weiser, Mark
A1 Cheng, Wei
A1 Cloninger, Robert
A1 Curtis, David
A1 Gejman, Pablo V
A1 Henskens, Frans
A1 Mattingsdal, Morten
A1 Oh, Sang-Yun
A1 Scott, Rodney
A1 Webb, Bradley
A1 Breen, Gerome
A1 Churchhouse, Claire
A1 Bulik, Cynthia M
A1 Daly, Mark
A1 Dichgans, Martin
A1 Faraone, Stephen V
A1 Guerreiro, Rita
A1 Holmans, Peter
A1 Kendler, Kenneth S
A1 Koeleman, Bobby
A1 Mathews, Carol A
A1 Price, Alkes
A1 Scharf, Jeremiah
A1 Sklar, Pamela
A1 Williams, Julie
A1 Wood, Nicholas W
A1 Cotsapas, Chris
A1 Palotie, Aarno
A1 Smoller, Jordan W
A1 Sullivan, Patrick
A1 Rosand, Jonathan
A1 Corvin, Aiden
A1 Neale, Benjamin M
A1 Schott, Jonathan M
A1 Anney, Richard
A1 Elia, Josephine
A1 Grigoroiu-Serbanescu, Maria
A1 Edenberg, Howard J
A1 Murray, Robin
K1 Brain Diseases
K1 Genetic Variation
K1 Genome-Wide Association Study
AB Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders. We also identified significant sharing between disorders and a number of brain phenotypes, including cognitive measures. Further, we conducted simulations to explore how statistical power, diagnostic misclassification, and phenotypic heterogeneity affect genetic correlations. These results highlight the importance of common genetic variation as a risk factor for brain disorders and the value of heritability-based methods in understanding their etiology.
PB American Association for the Advancement of Science
YR 2018
FD 2018-06-22
LK https://hdl.handle.net/10668/27760
UL https://hdl.handle.net/10668/27760
LA en
NO Brainstorm Consortium; Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, et al. Analysis of shared heritability in common disorders of the brain. Science. 2018 Jun 22;360(6395):eaap8757
NO This work was supported by grants 1R01MH10764901 and 5U01MH09443203 from the National Institute of Mental Health, as well as the Orion Farmos Research Foundation (V.A.) and the Fannie and John Hertz Foundation (H.K.F.). Consortium specific funding is detailed in the supplementary materials (“Study-specific acknowledgments”).
DS RISalud
RD Jun 15, 2025