RT Journal Article T1 Prediction of postpartum depression using multilayer perceptrons and pruning. A1 Tortajada, Salvador A1 García-Gomez, Juan M. A1 Vicente, Javier A1 Sanjuán, Julio A1 de Frutos, Rosa A1 Martín-Santos, Rocío A1 García-Esteve, Luisa A1 Gornemann, Isolde A1 Gutiérrez-Zotes, Alfonso A1 Canellas, Francesca A1 Carracedo, Angel A1 Gratacos, Monica A1 Guillamat, Roser A1 Baca-García, Enrique A1 Robles, Montserrat K1 Multilayer perceptron K1 Neural network K1 Pruning K1 Postpartum depression K1 España K1 Adulto K1 Algoritmos K1 Estudios de cohortes K1 Depresión postparto K1 Femenino K1 Predicción K1 Humanos K1 Modelos logísticos K1 Red nerviosa K1 Estudios prospectivos AB OBJECTIVE. The main goal of this paper is to obtain a classification model based on feed-forward multilayer perceptrons in order to improve postpartum depression prediction during the 32 weeks after childbirth with a high sensitivity and specificity and to develop a tool to be integrated in a decision support system for clinicians. MATERIALS AND METHODS. Multilayer perceptrons were trained on data from 1397 women who had just given birth, from seven Spanish general hospitals, including clinical, environmental and genetic variables. A prospective cohort study was made just after delivery, at 8 weeks and at 32 weeks after delivery. The models were evaluated with the geometric mean of accuracies using a hold-out strategy. RESULTS. Multilayer perceptrons showed good performance (high sensitivity and specificity) as predictive models for postpartum depression. CONCLUSIONS. The use of these models in a decision support system can be clinically evaluated in future work. The analysis of the models by pruning leads to a qualitative interpretation of the influence of each variable in the interest of clinical protocols. PB Schattauer SN 0026-1270 YR 2009 FD 2009 LK http://hdl.handle.net/10668/484 UL http://hdl.handle.net/10668/484 LA en NO Tortajada S, García-Gomez JM, Vicente J, Sanjuán J, de Frutos R, Martín-Santos R, et al. Prediction of postpartum depression using multilayer perceptrons and pruning. Methods Inf Med 2009; 48(3):291-8 NO Journal Article; Research Support, Non-U.S. Gov't; DS RISalud RD Apr 7, 2025