RT Journal Article
T1 Synergistic Effect of 3 ',4 '-Dihidroxifenilglicol and Hydroxytyrosol on Oxidative and Nitrosative Stress and Some Cardiovascular Biomarkers in an Experimental Model of Type 1 Diabetes Mellitus
A1 De La Cruz Cortes, Jose Pedro
A1 Vallejo-Carmona, Leticia
A1 Arrebola, Maria Monsalud
A1 Martin-Aurioles, Esther
A1 Rodriguez-Perez, Maria Dolores
A1 Ortega-Hombrados, Laura
A1 Verdugo, Cristina
A1 Fernandez-Prior, Maria Africa
A1 Bermudez-Oria, Alejandra
A1 Gonzalez-Correa, Jose Antonio
K1 hydroxytyrosol
K1 extra-virgin olive oil polyphenols
K1 3
K1 '
K1 ,4
K1 '
K1 -dihidroxifenilglicol
K1 oxidative stress
K1 cardiovascular
K1 Phenolic-compounds
K1 Olive oils
K1 Acetate
AB The objective of this study was to assess a possible synergistic effect of two extra-virgin olive oil polyphenols, 3,4,-dyhydroxyphenylglycol (DHPG) and hydroxytyrosol (HT), in an experimental model of type 1 diabetes. Seven groups of animals were studied: (1) Nondiabetic rats (NDR), (2) 2-month-old diabetic rats (DR), (3) DR treated with 5 mg/kg/day p.o. HT, (4) DR treated with 0.5 mg/kg/day p.o. DHPG, (5) DR treated with 1 mg/kg/day p.o. DHPG, (6) DR treated with HT + DHPG (0.5), (7) DR treated with HT + DHPG (1). Oxidative stress variables (lipid peroxidation, glutathione, total antioxidant activity, 8-isoprostanes, 8-hydroxy-2-deoxyguanosine, and oxidized LDL), nitrosative stress (3-nitrotyrosine), and some cardiovascular biomarkers (platelet aggregation, thromboxane B-2, prostacyclin, myeloperoxidase, and vascular cell adhesion protein 1 (VCAM-1)) were analyzed. The diabetic animals showed an imbalance in all of the analyzed variables. HT exerted an antioxidant and downregulatory effect on prothrombotic biomarkers while reducing the fall of prostacyclin. DHPG presented a similar, but quantitatively lower, profile. HT plus DHPG showed a synergistic effect in the reduction of oxidative and nitrosative stress, platelet aggregation, production of prostacyclin, myeloperoxidase, and VCAM-1. This synergism could be important for the development of functional oils enriched in these two polyphenols in the proportion used in this study.
PB Mdpi
YR 2021
FD 2021-12-01
LK https://hdl.handle.net/10668/26791
UL https://hdl.handle.net/10668/26791
LA en
DS RISalud
RD Apr 11, 2025