TY - JOUR AU - Garcia-Morales, Victoria AU - Gonzalez-Acedo, Anabel AU - Melguizo-Rodriguez, Lucia AU - Pardo-Moreno, Teresa AU - Costela-Ruiz, Victor Javier AU - Montiel-Troya, Maria AU - Ramos-Rodriguez, Juan Jose PY - 2021 DO - 10.3390/biomedicines9121910 UR - https://hdl.handle.net/10668/27784 T2 - Biomedicines AB - Alzheimer's disease (AD) is the most common cause of dementia. It is characterized by cognitive decline and progressive memory loss. The aim of this review was to update the state of knowledge on the pathophysiological mechanisms, diagnostic methods... LA - en PB - Mdpi KW - Alzheimer's disease KW - senile plaques KW - beta-amyloid protein KW - tau protein KW - diagnosis KW - biomarker KW - treatment KW - acetylcholinesterase inhibitors KW - immunotherapy KW - Cerebral amyloid angiopathy KW - Mild cognitive impairment KW - Insulin-degrading enzyme KW - National institute KW - Association workgroups KW - Plaque-formation KW - Transgenic mice KW - Risk-factors KW - Mixed-model KW - Mouse model TI - Current Understanding of the Physiopathology, Diagnosis and Therapeutic Approach to Alzheimer's Disease TY - research article VL - 9 ER -