RT Journal Article
T1 Isolation and characterization of new phenolic siderophores with antimicrobial properties from Pseudomonas sp. UIAU-6B
A1 Oluwabusola, Emmanuel T.
A1 Adebisi, Olusoji O.
A1 Reyes, Fernando
A1 Acquah, Kojo S.
A1 De la Cruz, Mercedes
A1 Mweetwa, Larry L.
A1 Rajakulendran, Joy E.
A1 Warner, Digby F.
A1 Hai, Deng
A1 Ebel, Rainer
A1 Jaspars, Marcel
K1 Mycobacterium tuberculosis
K1 Phenolic siderophores
K1 pseudomonine
K1 Pseudomonas sp
K1 vancomycin-sensitive Enterococcus faecium
K1 Natural-products
K1 Antibacterial activity
K1 Antifungal-activity
K1 Genome sequence
K1 Soil bacterium
K1 Salicylic-acid
K1 Iron
K1 Biosynthesis
K1 Accumulation
K1 Rhizosphere
AB Five new phenolic siderophores 1-5 were isolated from the organic extract of a culture broth in a modified SGG medium of Pseu-domonas sp. UIAU-6B, obtained from sediments collected from the Oyun river in North Central Nigeria. The structure of the new compounds, pseudomonin A-C (1-3) and pseudomobactin A and B (4 and 5) isolated alongside two known compounds, pseudomonine (6) and salicylic acid (7), were elucidated based on high-resolution mass spectrometry, 1D and 2D NMR analyses. The absolute configuration of the threonine residue in compounds 1-5 was determined by Marfey analysis. The antimicrobial eval-uation of compound 4 exhibited the most potent activity against vancomycin-sensitive Enterococcus faecium VS144754, followed by 3 and 5, with MIC values ranging from 8 to 32 mu g/mL. Compounds 2 and 3 exhibited moderate activity against Mycobacterium tuberculosis H37Rv, with MIC values of 7.8 and 15.6 mu g/mL, respectively. Plausible biosynthetic hypotheses toward the new com-pounds 1-5 were proposed.
PB Beilstein-institut
SN 1860-5397
YR 2021
FD 2021-09-14
LK http://hdl.handle.net/10668/19338
UL http://hdl.handle.net/10668/19338
LA en
DS RISalud
RD Apr 20, 2025