%0 Journal Article
%A Oluwabusola, Emmanuel T.
%A Adebisi, Olusoji O.
%A Reyes, Fernando
%A Acquah, Kojo S.
%A De la Cruz, Mercedes
%A Mweetwa, Larry L.
%A Rajakulendran, Joy E.
%A Warner, Digby F.
%A Hai, Deng
%A Ebel, Rainer
%A Jaspars, Marcel
%T Isolation and characterization of new phenolic siderophores with antimicrobial properties from Pseudomonas sp. UIAU-6B
%D 2021
%@ 1860-5397
%U http://hdl.handle.net/10668/19338
%X Five new phenolic siderophores 1-5 were isolated from the organic extract of a culture broth in a modified SGG medium of Pseu-domonas sp. UIAU-6B, obtained from sediments collected from the Oyun river in North Central Nigeria. The structure of the new compounds, pseudomonin A-C (1-3) and pseudomobactin A and B (4 and 5) isolated alongside two known compounds, pseudomonine (6) and salicylic acid (7), were elucidated based on high-resolution mass spectrometry, 1D and 2D NMR analyses. The absolute configuration of the threonine residue in compounds 1-5 was determined by Marfey analysis. The antimicrobial eval-uation of compound 4 exhibited the most potent activity against vancomycin-sensitive Enterococcus faecium VS144754, followed by 3 and 5, with MIC values ranging from 8 to 32 mu g/mL. Compounds 2 and 3 exhibited moderate activity against Mycobacterium tuberculosis H37Rv, with MIC values of 7.8 and 15.6 mu g/mL, respectively. Plausible biosynthetic hypotheses toward the new com-pounds 1-5 were proposed.
%K Mycobacterium tuberculosis
%K Phenolic siderophores
%K pseudomonine
%K Pseudomonas sp
%K vancomycin-sensitive Enterococcus faecium
%K Natural-products
%K Antibacterial activity
%K Antifungal-activity
%K Genome sequence
%K Soil bacterium
%K Salicylic-acid
%K Iron
%K Biosynthesis
%K Accumulation
%K Rhizosphere
%~