RT Journal Article
T1 DEPTOR in Skeletal Development and Diseases.
A1 Perez-Tejeiro, Jose Miguel
A1 Csukasi, Fabiana
K1 DEPTOR
K1 bone
K1 cartilage
K1 mTOR
K1 skeleton
AB Discovered in 2009, the DEP-domain containing mTOR-interacting protein, DEPTOR, is a known regulator of the mechanistic target of rapamycin (mTOR), an evolutionarily conserved kinase that regulates diverse cellular processes in response to environmental stimuli. DEPTOR was originally identified as a negative regulator of mTOR complexes 1 (mTORC1) and 2 (mTORC2). However, recent discoveries have started to unravel the roles of DEPTOR in mTOR-independent responses. In the past few years, mTOR emerged as an important regulator of skeletal development, growth, and homeostasis; the dysregulation of its activity contributes to the development of several skeletal diseases, both chronic and genetic. Even more recently, several groups have reported on the relevance of DEPTOR in skeletal biology through its action on mTOR-dependent and mTOR-independent pathways. In this review, we summarize the current understanding of DEPTOR in skeletal development and disease.
SN 1664-8021
YR 2021
FD 2021-05-27
LK https://hdl.handle.net/10668/24725
UL https://hdl.handle.net/10668/24725
LA en
DS RISalud
RD Apr 12, 2025