RT Journal Article
T1 High Prevalence of Systemic Autoimmune Diseases in Patients with Meniere's Disease
A1 Gazquez, Irene
A1 Soto-Varela, Andres
A1 Aran, Ismael
A1 Santos, Sofia
A1 Batuecas, Angel
A1 Trinidad, Gabriel
A1 Perez-Garrigues, Herminio
A1 Gonzalez-Oller, Carlos
A1 Acosta, Lourdes
A1 Lopez-Escamez, Jose A
K1 Interferon-gamma
K1 Tumor Necrosis Factor-alpha
K1 Enfermedad de Meniere
K1 Enfermedades Autoinmunes
K1 Pérdida Auditiva Sensorineural
K1 Vértigo
K1 Prevalencia
AB BACKGROUND. Autoimmunity appears to be associated with the pathophysiology of Meniere's disease (MD), an inner ear disorder characterized by episodes of vertigo associated with hearing loss and tinnitus. However, the prevalence of autoimmune diseases (AD) in patients with MD has not been studied in individuals with uni or bilateral sensorineural hearing loss (SNHL). METHODS AND FINDINGS. We estimated the prevalence of AD in 690 outpatients with MD with uni or bilateral SNHL from otoneurology clinics at six tertiary referral hospitals by using clinica criteria and an immune panel (lymphocyte populations, antinuclear antibodies, C3, C4 and proinflammatory cytokines TNFα, INFγ). The observed prevalence of rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and ankylosing spondylitis (AS) was higher than expected for the general population (1.39 for RA, 0.87 for SLE and 0.70 for AS, respectively). Systemic AD were more frequently observed in patients with MD and diagnostic criteria for migraine than cases with MD and tension-type headache (p = 0.007). There were clinical differences between patients with uni or bilateral SNHL, but no differences were found in the immune profile. Multiple linear regression showed that changes in lymphocytes subpopulations were associated with hearing loss and persistence of vertigo, suggesting a role for the immune response in MD. CONCLUSIONS. Despite some limitations, MD displays an elevated prevalence of systemic AD such as RA, SLE and AS. This finding, which suggests an autoimmune background in a subset of patients with MD, has important implications for the treatment of MD.
PB Public Library of Science (PLoS)
YR 2011
FD 2011-10-28
LK http://hdl.handle.net/10668/491
UL http://hdl.handle.net/10668/491
LA en
NO Gazquez I, Soto-Varela A, Aran I, Santos S, Batuecas A, Trinidad G, et al. High prevalence of systemic autoimmune diseases in patients with Menière's disease. PLoS ONE; 6(10):e26759
DS RISalud
RD Apr 19, 2025