RT Journal Article
T1 mPGES-1 (Microsomal Prostaglandin E Synthase-1) Mediates Vascular Dysfunction in Hypertension Through Oxidative Stress.
A1 Avendaño, María S
A1 García-Redondo, Ana B
A1 Zalba, Guillermo
A1 González-Amor, María
A1 Aguado, Andrea
A1 Martínez-Revelles, Sonia
A1 Beltrán, Luis M
A1 Camacho, Mercedes
A1 Cachofeiro, Victoria
A1 Alonso, María J
A1 Salaices, Mercedes
A1 Briones, Ana M
K1 angiotensin II
K1 hypertension
K1 oxidative stress
K1 prostaglandins
K1 vascular remodeling
AB mPGES-1 (microsomal prostaglandin E synthase-1), the downstream enzyme responsible for PGE2 (prostaglandin E2) synthesis in inflammatory conditions and oxidative stress are increased in vessels from hypertensive animals. We evaluated the role of mPGES-1-derived PGE2 in the vascular dysfunction and remodeling in hypertension and the possible contribution of oxidative stress. We used human peripheral blood mononuclear cells from asymptomatic patients, arteries from untreated and Ang II (angiotensin II)-infused mPGES-1-/- and mPGES-1+/+ mice, and vascular smooth muscle cells exposed to PGE2 In human cells, we found a positive correlation between mPGES-1 mRNA and carotid intima-media thickness (r=0.637; P
YR 2018
FD 2018-06-11
LK http://hdl.handle.net/10668/12577
UL http://hdl.handle.net/10668/12577
LA en
DS RISalud
RD Apr 10, 2025