TY  - JOUR
AU  - Fernández, Gerónimo
AU  - Moraga, Ana
AU  - Cuartero, María I
AU  - García-Culebras, Alicia
AU  - Peña-Martínez, Carolina
AU  - Pradillo, Jesús M
AU  - Hernández-Jiménez, Macarena
AU  - Sacristán, Silvia
AU  - Ayuso, M Irene
AU  - Gonzalo-Gobernado, Rafael
AU  - Fernández-López, David
AU  - Martín, M Elena
AU  - Moro, María A
AU  - González, Victor M
AU  - Lizasoain, Ignacio
PY  - 2018
DO  - 10.1016/j.ymthe.2018.05.019
UR  - http://hdl.handle.net/10668/12605
T2  - Molecular therapy : the journal of the American Society of Gene Therapy
AB  - Since Toll-like receptor 4 (TLR4) mediates brain damage after stroke, development of TLR4 antagonists is a promising therapeutic strategy for this disease. Our aim was to generate TLR4-blocking DNA aptamers to be used for stroke treatment. From a...
LA  - en
KW  - SELEX
KW  - TLR4
KW  - aptamer
KW  - infarction
KW  - inflammation
KW  - ischemia
KW  - stroke
KW  - therapy
KW  - Animals
KW  - Aptamers, Nucleotide
KW  - Disease Models, Animal
KW  - Humans
KW  - Infarction, Middle Cerebral Artery
KW  - Mice
KW  - Rats
KW  - SELEX Aptamer Technique
KW  - Signal Transduction
KW  - Stroke
KW  - Toll-Like Receptor 4
TI  - TLR4-Binding DNA Aptamers Show a Protective Effect against Acute Stroke in Animal Models.
TY  - research article
VL  - 26
ER  -