RT Journal Article T1 Determinants of change in physical activity during moderate-to-severe COPD exacerbation. A1 Esteban, Cristóbal A1 Quintana, José M A1 Garcia-Gutierrez, Susana A1 Anton-Ladislao, Ane A1 Gonzalez, Nerea A1 Baré, Marisa A1 Fernández de Larrea, Nerea A1 Rivas-Ruiz, Francisco A1 IRYSS-COPD group, K1 COPD exacerbations K1 physical activity K1 prospective cohort study AB Data are scarce on patient physical activity (PA) level during exacerbations of chronic obstructive pulmonary disease (eCOPD). The objective of the study was to evaluate the level and determinants of change in PA during an eCOPD. We conducted a prospective cohort study with recruitment from emergency departments (EDs) of 16 participating hospitals from June 2008 to September 2010. Data were recorded on socioeconomic characteristics, dyspnea, forced expiratory volume in 1 second (FEV1%), comorbidities, health-related quality of life, factors related to exacerbation, and PA in a stable clinical condition and during the eCOPD episode. We evaluated 2,487 patients. Common factors related to the change in PA during hospital admission or 7 days after discharge to home from the ED were lower PA at baseline and during the first 24 hours after the index evaluation. Age, quality of life, living alone, length of hospital stay, and use of anticholinergic or systemic corticosteroids in treating the exacerbation were associated with the change in PA among hospitalized patients. Predictors of change among patients not admitted to hospital were baseline FEV1% and dyspnea at rest on ED arrival. Among the patients evaluated in an ED for an eCOPD, the level and change in PA was markedly variable. Factors associated with exacerbation (PA 24 hours after admission, medication during admission, and length of hospital stay) and variables reflecting patients' stable clinical condition (low level of PA, age, quality of life, FEV1%) are predictors of the change in PA during a moderate-to-severe eCOPD. YR 2016 FD 2016-02-03 LK http://hdl.handle.net/10668/9848 UL http://hdl.handle.net/10668/9848 LA en DS RISalud RD Apr 6, 2025