RT Journal Article
T1 Effectiveness of an individualized program of muscular strength and endurance with aerobic training for improving germ cell cancer-related fatigue in men undergoing chemotherapy: EFICATEST study protocol for a randomized controlled trial.
A1 Cuesta-Vargas, Antonio Ignacio
A1 Carabantes, Francisco
A1 Caracuel, Zaira
A1 Conejo, Inmaculada
A1 Alba, Emilio
K1 Testicular cancer
K1 Germ cell cancer
K1 Physical exercise
K1 Cancer-related fatigue
K1 Chemotherapy
K1 Clinical rules
K1 Metabolomics
K1 Grupos control
K1 Fatiga
K1 Músculo esquelético
K1 Humanos
K1 Fuerza muscular
K1 Neoplasias
K1 Neoplasias de células germinales y embrionarias
K1 Salud pública
K1 Ejercicio físico
AB BACKGROUNDPatients with testicular germ cell cancer (GCC) have a high cure rate; however, cancer-related fatigue is the most common complication among patients with GCC undergoing treatment with chemotherapy. Although exercise is widely recommended, information about the physio-pathological effects of cancer therapy on skeletal muscle is very limited. Our aim is to evaluate the effects of an individualized program of muscular strength and endurance with aerobic training on cancer-related fatigue.METHODS/DESIGNThe present study is a randomized controlled trial comparing an individualized program of muscular strength and endurance with aerobic training compared to a control group. We will conduct this trial in patients undergoing chemotherapy, recruited by the Department of Oncology of Virgen de la Victoria Hospital (Málaga). Patients will be included and evaluated before the first cycle of chemotherapy and assigned randomly to the experimental or control group. Cancer-related fatigue, physical condition and biological samples will be measured at the beginning and at the end of an 8-week intervention by the same evaluator, who will be unaware of the allocation of participants to each group. Furthermore, there will be monitoring for 6 months (24 weeks) after training for all outcome variables.DISCUSSIONThis study hopes to offer patients with GCC an individualized exercise program with aerobic training for cancer-related fatigue. Such a scheme, if beneficial, could be implemented successfully within public health.TRIAL REGISTRATIONClinicalTrials.gov Identifier: NCT02433197 . Date of registration: 13 April 2015.
PB Biomed Central
YR 2016
FD 2016-01-05
LK http://hdl.handle.net/10668/2398
UL http://hdl.handle.net/10668/2398
LA en
NO Cuesta-Vargas AI, Carabantes F, Caracuel Z, Conejo I, Alba E. Effectiveness of an individualized program of muscular strength and endurance with aerobic training for improving germ cell cancer-related fatigue in men undergoing chemotherapy: EFICATEST study protocol for a randomized controlled trial. Trials. 2016; 17:8
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 8, 2025