RT Journal Article
T1 Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug.
A1 García-Vilas, Javier A
A1 Martínez-Poveda, Beatriz
A1 Quesada, Ana R
A1 Medina, Miguel Ángel
K1 (+)-aeroplysinin-1
K1 angiogenesis
K1 cancer
K1 inflammation
K1 marine drugs
K1 sponges
AB Organisms lacking external defense mechanisms have developed chemical defense strategies, particularly through the production of secondary metabolites with antibiotic or repellent effects. Secondary metabolites from marine organisms have proven to be an exceptionally rich source of small molecules with pharmacological activities potentially beneficial to human health. (+)-Aeroplysinin-1 is a secondary metabolite isolated from marine sponges with a wide spectrum of bio-activities. (+)-Aeroplysinin-1 has potent antibiotic effects on Gram-positive bacteria and several dinoflagellate microalgae causing toxic blooms. In preclinical studies, (+)-aeroplysinin-1 has been shown to have promising anti-inflammatory, anti-angiogenic and anti-tumor effects. Due to its versatility, (+)-aeroplysinin-1 might have a pharmaceutical interest for the treatment of different pathologies.
YR 2015
FD 2015-12-22
LK http://hdl.handle.net/10668/9679
UL http://hdl.handle.net/10668/9679
LA en
DS RISalud
RD Apr 9, 2025