RT Journal Article
T1 Association of Streptococcus gallolyticus subspecies gallolyticus with colorectal cancer: Serological evidence.
A1 Butt, Julia
A1 Romero-Hernández, Beatriz
A1 Pérez-Gómez, Beatriz
A1 Willhauck-Fleckenstein, Martina
A1 Holzinger, Dana
A1 Martin, Vicente
A1 Moreno, Victor
A1 Linares, Cristina
A1 Dierssen-Sotos, Trinidad
A1 Barricarte, Aurelio
A1 Tardón, Adonina
A1 Altzibar, Jone M
A1 Moreno-Osset, Eduardo
A1 Franco, Francisco
A1 Requena, Rocío Olmedo
A1 Huerta, José María
A1 Michel, Angelika
A1 Waterboer, Tim
A1 Castaño-Vinyals, Gemma
A1 Kogevinas, Manolis
A1 Pollán, Marina
A1 Boleij, Annemarie
A1 de Sanjosé, Silvia
A1 Del Campo, Rosa
A1 Tjalsma, Harold
A1 Aragonés, Nuria
A1 Pawlita, Michael
K1 antibodies
K1 case-control study
K1 epidemiology
K1 gastrointestinal cancer
K1 infection
K1 pilus protein
AB The colonic opportunist Streptococcus gallolyticus subspecies gallolyticus (SGG) is potentially associated with colorectal cancer (CRC). Large-scale seroepidemiological data for SGG antibodies and their possible association with CRC is currently missing. Associations between CRC and antibody responses to SGG were examined in 576 CRC cases and 576 controls matched by sex, age and province from a population-based multicase-control project (MCC-Spain). MCC-Spain was conducted between 2008 and 2013 in 12 Spanish provinces. Antibody responses to recombinant affinity-purified SGG pilus proteins Gallo1569, 2039, 2178 and 2179 were analysed by multiplex serology. Polyomavirus (PyV) JC VP1 and PyV 6 VP1 proteins served as disease-specificity controls. In the control population, antibody responses to pilus proteins were mostly weak. Antibody responses to individual pilus proteins Gallo2039 (OR: 1.58, 95% CI: 1.09-2.28), Gallo2178 (OR: 1.58, 95% CI: 1.09-2.30) and Gallo2179 (OR: 1.45, 95% CI: 1.00-2.11) were significantly associated with CRC risk. The association was stronger for positivity to two or more pilus proteins of Gallo1569, Gallo2178 and Gallo2179 (OR:1.93, 95% CI: 1.04-3.56) and for double-positivity to Gallo2178 and Gallo2179 (OR: 3.54, 95% CI: 1.49-8.44). The association between SGG infection and CRC risk was stronger among individuals younger than 65 years. For the first time we demonstrated a statistically significant association of exposure to SGG antigens and CRC in a large seroepidemiological study. These results should stimulate further studies on the role of SGG in CRC pathogenesis.
YR 2015
FD 2015-11-20
LK http://hdl.handle.net/10668/9614
UL http://hdl.handle.net/10668/9614
LA en
DS RISalud
RD Apr 7, 2025