RT Journal Article
T1 Visual Acuity and Number of Amniotic Membrane Layers as Indicators of Efficacy in Amniotic Membrane Transplantation for Corneal Ulcers: A Multicenter Study.
A1 Lacorzana, Javier
A1 Campos, Antonio
A1 Brocal-Sánchez, Marina
A1 Marín-Nieto, Juan
A1 Durán-Carrasco, Oswaldo
A1 Fernández-Núñez, Esly C
A1 López-Jiménez, Andrés
A1 González-Gutiérrez, Jose L
A1 Petsoglou, Constantinos
A1 Serrano, Jose L García
K1 amniotic membrane
K1 amniotic membrane transplantation
K1 cornea
K1 corneal ulcer
K1 corneal ulceration
K1 non healing corneal ulcer
K1 persistent epithelial defects
K1 visual acuity
AB To evaluate new indicators in the efficacy of amniotic membrane transplantation (AMT) for non-healing corneal ulcers (NHCUs). Retrospective, multicenter study. In total, 223 AMTs for NHCU in 191 patients were assessed. The main outcomes studied were the success rate of AMT (complete re-epithelization), postoperative visual acuity (VA) gain, and number of AM layers transplanted. The overall AMT success rate was 74.4%. In 92% of our patients VA stability or improvement. Postoperative VA was significantly higher than preoperative VA in the entire cohort (p  AMT is not only beneficial in achieving complete re-epithelialization in NHCUs but also in improving postoperative VA; these improvements are independent of etiologies of ulcers. Furthermore, the use of monolayer AMT seems to be a more appropriate option than multilayer AMT for NHCU since the multilayer AMT did not present better outcomes (success rate and VA gain) compared to monolayer AMT in the different types of ulcers studied.
SN 2077-0383
YR 2021
FD 2021-07-22
LK http://hdl.handle.net/10668/18329
UL http://hdl.handle.net/10668/18329
LA en
DS RISalud
RD Apr 18, 2025