RT Generic T1 Evaluation of symptomatic patients without airflow obstruction: back to the future A1 Luis Lopez-Campos, Jose A1 Alcazar, Bernardino K1 Copd assessment test K1 Pulmonary-disease K1 Smokers AB Throughout recent decades, the concept of chronic obstructive pulmonary disease ( COPD ) has been evolving from initial clinical observations of single cardinal symptoms and morphological manifestations in the form of chronic bronchitis and emphysema . The 1959 CIBA Guest Symposium defined chronic bronchitis and emphysema in clinical and anatomic terms respectively. Although neither definition used any physiologic criteria, COPD is now defined in functional terms. According to current criteria, COPD is diagnosed in relation to the appearance of an airflow obstruction that is not fully reversible and the history of tobacco exposure (1). Although symptoms help the clinician to suspect the disease (2), the final individual diagnosis relies on a confirmed risk exposure in the medical record and the presence of this non-reversible airway obstruction (1). PB AME Publishing Company SN 2072-1439 YR 2016 FD 2016-12 LK http://hdl.handle.net/10668/19472 UL http://hdl.handle.net/10668/19472 LA en NO Lopez-Campos JL, Alcazar B. Evaluation of symptomatic patients without airflow obstruction: back to the future. J Thorac Dis 2016;8(12):E1657-E1660 DS RISalud RD Jul 6, 2025