RT Journal Article
T1 Relevance of Reference Centers in Sarcoma Care and Quality Item Evaluation: Results from the Prospective Registry of the Spanish Group for Research in Sarcoma (GEIS).
A1 Martin-Broto, Javier
A1 Hindi, Nadia
A1 Cruz, Josefina
A1 Martinez-Trufero, Javier
A1 Valverde, Claudia
A1 De-Sande, Luis M
A1 Sala, Angeles
A1 Bellido, Lorena
A1 De-Juan, Ana
A1 Rubio-Casadevall, Jordi
A1 Diaz-Beveridge, Roberto
A1 Cubedo, Ricardo
A1 Tendero, Oscar
A1 Salinas, Diego
A1 Gracia, Isidro
A1 Ramos, Rafael
A1 Bague, Silvia
A1 Gutierrez, Antonio
A1 Duran-Moreno, Jose
A1 Lopez-Pousa, Antonio
K1 Diagnostic process
K1 Multidisciplinary management
K1 Outcome
K1 Reference centers
K1 Sarcoma
AB Reference centers (RCs) are a key point for improving the survival of patients with soft‐ tissue sarcomas (STS). The aim of this study was to evaluate selected items in the management of patients with STS, comparing results between RC and local hospitals (LHs). Materials and MethodsDiagnostic and therapeutic data from patients diagnosed between January 2004 and December 2011 were collected. Correlation with outcome was performed.ResultsA total of 622 sarcomas were analyzed, with a median follow‐up of 40 months. Imaging of primary tumor preoperatively (yes vs. no) correlated with a higher probability of free surgical margins (77.4% versus 53.7%; p = .006). The provenance of the biopsy (RC vs. LH) significantly affected relapse ‐free survival (RFS; 3‐year RFS 66% vs. 46%, respectively; p = .019). Likewise, 3‐year RFS was significantly worse in cases with infiltrated (55.6%) or unknown (43.4%) microscopic surgical margins compared with free margins (63.6%; p < .001). Patients managed by RCs had a better 3‐year overall survival compared with those managed by LHs (82% vs. 70.4%, respectively; p = .003). Perioperative chemotherapy in high‐ risk STS, more frequently administered in RCs than in LHs, resulted in significantly better 3‐year RFS (66% vs. 44%; p = .011). In addition, patients with stage IV disease treated in RCs survived significantly longer compared with those in LHs (30.4 months vs. 18.5 months; p = .036). ConclusionOur series indicate that selected quality‐of‐care items were accomplished better by RCs over LHs, all with significant prognostic value in patients with STS. Early referral to an RC should be mandatory if the aim is to improve the survival of patients with STS.
PB Oxford University Press
YR 2018
FD 2018-11-08
LK http://hdl.handle.net/10668/13162
UL http://hdl.handle.net/10668/13162
LA en
NO Martin-Broto J, Hindi N, Cruz J, Martinez-Trufero J, Valverde C, De Sande LM, et al. Relevance of Reference Centers in Sarcoma Care and Quality Item Evaluation: Results from the Prospective Registry of the Spanish Group for Research in Sarcoma (GEIS). Oncologist. 2019 Jun;24(6):e338-e346.
DS RISalud
RD Jul 31, 2025