RT Journal Article
T1 Legume consumption and risk of all-cause, cardiovascular, and cancer mortality in the PREDIMED study.
A1 Papandreou, Christopher
A1 Becerra-Tomás, Nerea
A1 Bulló, Mònica
A1 Martínez-González, Miguel Ángel
A1 Corella, Dolores
A1 Estruch, Ramon
A1 Ros, Emilio
A1 Arós, Fernando
A1 Schroder, Helmut
A1 Fitó, Montserrat
A1 Serra-Majem, Lluís
A1 Lapetra, José
A1 Fiol, Miquel
A1 Ruiz-Canela, Miguel
A1 Sorli, Jose V
A1 Salas-Salvadó, Jordi
K1 Cancer
K1 Cardiovascular
K1 Legumes
K1 Mortality
K1 PREDIMED
AB Limited prospective studies have examined the association between legumes consumption and mortality, whereas scarce, if at all, previous studies have evaluated such associations taking into consideration specific grain legumes. We aimed to investigate the association between total legumes consumption and grain legumes species (dry beans, chickpeas, lentils, and fresh peas) with all-cause, cardiovascular disease (CVD), cancer and other-cause mortality among elderly Mediterranean individuals at high CVD risk. We prospectively assessed 7216 participants from the PREvención con DIeta MEDiterránea study. Dietary intake was assessed at baseline and yearly during follow-up by using a validated food frequency questionnaire. During a median follow-up of 6.0 years, 425 total deaths, 103 CVD deaths, 169 cancer deaths and 153 due to other-causes deaths occurred. Hazard ratios (HRs) [95% confidence interval (CI)] of CVD mortality were 1.52 (1.02-2.89) (P-trend = 0.034) and 2.23 (1.32-3.78) (P-trend = 0.002) for the 3rd tertile of total legumes and dry beans consumption, respectively, compared with the 1st tertile. When comparing extreme tertiles, higher total legumes and lentils consumption was associated with 49% (HR: 0.51; 95% CI: 0.31-0.84; P-trend = 0.009) and 37% (HR: 0.63; 95% CI: 0.40-0.98; P-trend = 0.049) lower risk of cancer mortality. Similar associations were observed for CVD death in males and for cancer death in males, obese and diabetic participants. These findings support the benefits of legumes consumption for cancer mortality prevention which may be counterbalanced by their higher risk for CVD mortality. The trial is registered at http://www.controlled-trials.com (ISRCTN35739639). Registration date: 5th October 2005.
YR 2018
FD 2018-01-09
LK http://hdl.handle.net/10668/12032
UL http://hdl.handle.net/10668/12032
LA en
DS RISalud
RD Apr 8, 2025