TY - GEN AU - Gonzalez-Larriba, Jose Luis AU - Lazaro-Quintela, Martin AU - Cobo, Manuel AU - Domine, Manuel AU - Majem, Margarita AU - Garcia-Campelo, Rosario PY - 2017 DO - 10.21037/tlcr.2017.10.03 SN - 2218-6751 UR - http://hdl.handle.net/10668/19479 T2 - Translational lung cancer research AB - One of the most important advances in the treatment of non-small cell lung cancer (NSCLC) has been the identification of molecular alterations vulnerable to targeted inhibition, such as mutations in the epidermal growth factor receptor (EGFR) gene.... LA - en PB - AME Publishing Company KW - Epidermal growth factor receptor (EGFR) KW - tyrosine kinase inhibitor (TKI) KW - osimertinib KW - liquid biopsy KW - rebiopsy KW - Egfr t790m mutation KW - Acquired-resistance KW - Open-label KW - Phase-iii KW - 1st-line treatment KW - Met amplification KW - Carboplatin-paclitaxel KW - Gefitinib resistance KW - Gene-mutations KW - Nsclc patients KW - Carcinoma, Non-Small-Cell Lung KW - Mutation, Missense KW - Drug Resistance, Neoplasm KW - Protein Kinase Inhibitors KW - Precision Medicine KW - Biopsy KW - Antineoplastic Agents KW - Treatment Outcome TI - Clinical management of epidermal growth factor receptor mutation-positive non-small cell lung cancer patients after progression on previous epidermal growth factor receptor tyrosine kinase inhibitors: the necessity of repeated molecular analysis TY - review VL - 6 ER -