RT Journal Article
T1 Marine-Derived Compounds Targeting Topoisomerase II in Cancer Cells: A Review.
A1 Greco, Giulia
A1 Pellicioni, Valentina
A1 Cruz-Chamorro, Ivan
A1 Attisani, Giuseppe
A1 Stefanelli, Claudio
A1 Fimognari, Carmela
K1 cancer chemotherapy
K1 marine bacteria
K1 marine compounds
K1 marine fungi
K1 marine invertebrates
K1 sponges
K1 topoisomerase II
AB Cancer affects more than 19 million people and is the second leading cause of death in the world. One of the principal strategies used in cancer therapy is the inhibition of topoisomerase II, involved in the survival of cells. Side effects and adverse reactions limit the use of topoisomerase II inhibitors; hence, research is focused on discovering novel compounds that can inhibit topoisomerase II and have a safer toxicological profile. Marine organisms are a source of secondary metabolites with different pharmacological properties including anticancer activity. The objective of this review is to present and discuss the pharmacological potential of marine-derived compounds whose antitumor activity is mediated by topoisomerase II inhibition. Several compounds derived from sponges, fungi, bacteria, ascidians, and other marine sources have been demonstrated to inhibit topoisomerase II. However, some studies only report docking interactions, whereas others do not fully explain the mechanisms of topoisomerase II inhibition. Further in vitro and in vivo studies are needed, as well as a careful toxicological profile evaluation with a focus on cancer cell selectivity.
YR 2022
FD 2022-10-27
LK http://hdl.handle.net/10668/21420
UL http://hdl.handle.net/10668/21420
LA en
DS RISalud
RD Apr 7, 2025