RT Journal Article
T1 Early Nutrition and Later Excess Adiposity during Childhood: A Narrative Review.
A1 Iglesia Altaba, Iris
A1 Larque, Elvira
A1 Mesa, Maria Dolores
A1 Blanco-Carnero, Jose Eliseo
A1 Gomez-Llorente, Carolina
A1 Rodriguez-Martinez, Gerardo
A1 Moreno, Luis A
K1 Adiposity
K1 Epigenetics
K1 Infant feeding
K1 Microbiome
K1 Programming
AB Studies on childhood obesity mainly focus on the genetic component and on the lifestyle that may be associated with the development of obesity. However, the study of perinatal factors in their programming effect toward future obesity in children or adults is somewhat more recent, and there are still mechanisms to be disentangled. In this narrative review, a comprehensive route based on the influence of some early factors in life in the contribution to later obesity development is presented. Maternal pre-pregnancy BMI and gestational weight gain have been pointed out as independent determinants of infant later adiposity. Lifestyle interventions could have an impact on pregnant mothers through epigenetic mechanisms capable of redirecting the genetic expression of their children toward a future healthy weight and body composition and dietary-related microbiome modifications in mothers and newborns might also be related. After birth, infant feeding during the first months of life is directly associated with its body composition and nutritional status. From this point of view, all the expert committees in the world are committed to promote exclusive breastfeeding up to 6 months of age and to continue at least until the first year of life together with complementary feeding based on healthy dietary patterns such as Mediterranean Diet. To develop future effective programs to tackle early obesity, it is necessary not only by controlling lifestyle behaviors like infant feeding but also understanding the role of other mechanisms like the effect of perinatal factors such as maternal diet during pregnancy, epigenetics, or microbiome.
PB S. Karger AG
YR 2021
FD 2021-11-09
LK http://hdl.handle.net/10668/20189
UL http://hdl.handle.net/10668/20189
LA en
NO Iglesia Altaba I, Larqué E, Mesa MD, Blanco-Carnero JE, Gomez-Llorente C, Rodríguez-Martínez G, et al. Early Nutrition and Later Excess Adiposity during Childhood: A Narrative Review. Horm Res Paediatr. 2022;95(2):112-119.
DS RISalud
RD Apr 11, 2025