TY  - JOUR
AU  - Hajji, Nabil
AU  - Garcia-Revilla, Juan
AU  - Soto, Manuel Sarmiento
AU  - Perryman, Richard
AU  - Symington, Jake
AU  - Quarles, Chad C
AU  - Healey, Deborah R
AU  - Guo, Yijie
AU  - Orta-Vazquez, Manuel Luis
AU  - Mateos-Cordero, Santiago
AU  - Shah, Khalid
AU  - Bomalaski, John
AU  - Anichini, Giulio
AU  - Tzakos, Andreas G
AU  - Crook, Timothy
AU  - O'Neill, Kevin
AU  - Scheck, Adrienne C
AU  - Venero, Jose Luis
AU  - Syed, Nelofer
PY  - 2022
DO  - 10.1172/JCI142137
UR  - http://hdl.handle.net/10668/20205
T2  - The Journal of clinical investigation
AB  - New approaches for the management of glioblastoma (GBM) are an urgent and unmet clinical need. Here, we illustrate that the efficacy of radiotherapy for GBM is strikingly potentiated by concomitant therapy with the arginine-depleting agent ADI-PEG20...
LA  - en
PB  - American Society for Clinical Investigation
KW  - Amino acid metabolism
KW  - Brain cancer
KW  - Nitric oxide
KW  - Oncology
KW  - Therapeutics
KW  - Antineoplastic Agents
KW  - Arginine
KW  - Argininosuccinate Synthase
KW  - Cell Line, Tumor
KW  - Glioblastoma
KW  - Humans
KW  - Hydrolases
KW  - Microglia
KW  - Polyethylene Glycols
TI  - Arginine deprivation alters microglial polarity and synergizes with radiation to eradicate non-arginine-auxotrophic glioblastoma tumors.
TY  - research article
VL  - 132
ER  -