RT Journal Article T1 Coffee and tea consumption and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition. A1 Sen, Abhijit A1 Papadimitriou, Nikos A1 Lagiou, Pagona A1 Perez-Cornago, Aurora A1 Travis, Ruth C A1 Key, Timothy J A1 Murphy, Neil A1 Gunter, Marc A1 Freisling, Heinz A1 Tzoulaki, Ioanna A1 Muller, David C A1 Cross, Amanda J A1 Lopez, David S A1 Bergmann, Manuela A1 Boeing, Heiner A1 Bamia, Christina A1 Kotanidou, Anastasia A1 Karakatsani, Anna A1 Tjønneland, Anne A1 Kyrø, Cecilie A1 Outzen, Malene A1 Redondo, María-Luisa A1 Cayssials, Valerie A1 Chirlaque, Maria-Dolores A1 Barricarte, Aurelio A1 Sanchez-Perez, Maria-Jose A1 Larrañaga, Nerea A1 Tumino, Rosario A1 Grioni, Sara A1 Palli, Domenico A1 Caini, Saverio A1 Sacerdote, Carlotta A1 Bueno-de-Mesquita, Bas A1 Kühn, Tilman A1 Kaaks, Rudolf A1 Nilsson, Lena Maria A1 Landberg, Rikard A1 Wallström, Peter A1 Drake, Isabel A1 Bech, Bodil Hammer A1 Overvad, Kim A1 Aune, Dagfinn A1 Khaw, Kay-Tee A1 Riboli, Elio A1 Trichopoulos, Dimitrios A1 Trichopoulou, Antonia A1 Tsilidis, Konstantinos K K1 EPIC K1 caffeinated K1 coffee K1 decaffeinated K1 prostate cancer K1 tea AB The epidemiological evidence regarding the association of coffee and tea consumption with prostate cancer risk is inconclusive, and few cohort studies have assessed these associations by disease stage and grade. We examined the associations of coffee (total, caffeinated and decaffeinated) and tea intake with prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition. Among 142,196 men, 7,036 incident prostate cancer cases were diagnosed over 14 years of follow-up. Data on coffee and tea consumption were collected through validated country-specific food questionnaires at baseline. We used Cox proportional hazards regression models to compute hazard ratios (HRs) and 95% confidence intervals (CI). Models were stratified by center and age, and adjusted for anthropometric, lifestyle and dietary factors. Median coffee and tea intake were 375 and 106 mL/day, respectively, but large variations existed by country. Comparing the highest (median of 855 mL/day) versus lowest (median of 103 mL/day) consumers of coffee and tea (450 vs. 12 mL/day) the HRs were 1.02 (95% CI, 0.94-1.09) and 0.98 (95% CI, 0.90-1.07) for risk of total prostate cancer and 0.97 (95% CI, 0.79-1.21) and 0.89 (95% CI, 0.70-1.13) for risk of fatal disease, respectively. No evidence of association was seen for consumption of total, caffeinated or decaffeinated coffee or tea and risk of total prostate cancer or cancer by stage, grade or fatality in this large cohort. Further investigations are needed to clarify whether an association exists by different preparations or by concentrations and constituents of these beverages. YR 2018 FD 2018-11-16 LK http://hdl.handle.net/10668/12643 UL http://hdl.handle.net/10668/12643 LA en DS RISalud RD Apr 14, 2025