RT Journal Article
T1 VISMapper: ultra-fast exhaustive cartography of viral insertion sites for gene therapy.
A1 Juanes, José M
A1 Gallego, Asunción
A1 Tárraga, Joaquín
A1 Chaves, Felipe J
A1 Marín-Garcia, Pablo
A1 Medina, Ignacio
A1 Arnau, Vicente
A1 Dopazo, Joaquín
K1 Gene therapy
K1 Genome viewer
K1 Sequence mapping
K1 Viral insertion
K1 Viral integration
AB The possibility of integrating viral vectors to become a persistent part of the host genome makes them a crucial element of clinical gene therapy. However, viral integration has associated risks, such as the unintentional activation of oncogenes that can result in cancer. Therefore, the analysis of integration sites of retroviral vectors is a crucial step in developing safer vectors for therapeutic use. Here we present VISMapper, a vector integration site analysis web server, to analyze next-generation sequencing data for retroviral vector integration sites. VISMapper can be found at: http://vismapper.babelomics.org . Because it uses novel mapping algorithms VISMapper is remarkably faster than previous available programs. It also provides a useful graphical interface to analyze the integration sites found in the genomic context.
YR 2017
FD 2017-09-20
LK http://hdl.handle.net/10668/11597
UL http://hdl.handle.net/10668/11597
LA en
DS RISalud
RD Apr 10, 2025