RT Journal Article
T1 DEPTOR in Skeletal Development and Diseases
A1 Perez-Tejeiro, Jose Miguel
A1 Csukasi, Fabiana
K1 DEPTOR
K1 mTOR
K1 Skeleton
K1 Bone
K1 Cartilage
K1 Proteína reguladora asociada a mTOR
K1 Diana mecanicista del complejo 1 de la rapamicina
K1 Esqueleto
K1 Huesos
K1 Cartílago
AB Discovered in 2009, the DEP-domain containing mTOR-interacting protein, DEPTOR, is a known regulator of the mechanistic target of rapamycin (mTOR), an evolutionarily conserved kinase that regulates diverse cellular processes in response to environmental stimuli. DEPTOR was originally identified as a negative regulator of mTOR complexes 1 (mTORC1) and 2 (mTORC2). However, recent discoveries have started to unravel the roles of DEPTOR in mTOR-independent responses. In the past few years, mTOR emerged as an important regulator of skeletal development, growth, and homeostasis; the dysregulation of its activity contributes to the development of several skeletal diseases, both chronic and genetic. Even more recently, several groups have reported on the relevance of DEPTOR in skeletal biology through its action on mTORdependent and mTOR-independent pathways. In this review, we summarize the current understanding of DEPTOR in skeletal development and disease.
PB Frontiers
YR 2021
FD 2021-05-27
LK http://hdl.handle.net/10668/4091
UL http://hdl.handle.net/10668/4091
LA en
NO Perez-Tejeiro JM, Csukasi F. DEPTOR in Skeletal Development and Diseases. Front Genet. 2021 May 27;12:667283
DS RISalud
RD Mar 14, 2025