TY  - JOUR
AU  - Blasco, Lucia
AU  - Ambroa, Anton
AU  - Trastoy, Rocio
AU  - Bleriot, Ines
AU  - Moscoso, Miriam
AU  - Fernández-Garcia, Laura
AU  - Perez-Nadales, Elena
AU  - Fernández-Cuenca, Felipe
AU  - Torre-Cisneros, Julian
AU  - Oteo-Iglesias, Jesus
AU  - Oliver, Antonio
AU  - Canton, Rafael
AU  - Kidd, Tim
AU  - Navarro, Ferran
AU  - Miró, Elisenda
AU  - Pascual, Alvaro
AU  - Bou, German
AU  - Martínez-Martínez, Luis
AU  - Tomas, Maria
PY  - 2020
DO  - 10.1038/s41598-020-64145-7
UR  - http://hdl.handle.net/10668/3789
T2  - Scientific Reports
AB  - The emergence of multidrug resistant (MDR) pathogenic bacteria is jeopardizing the value of antimicrobials, which had previously changed the course of medical science. In this study, we identified endolysins ElyA1 and ElyA2 (GH108-PG3 family), present...
LA  - en
PB  - Springer Nature
KW  - Anti-infective agents
KW  - Drug resistance, multiple, bacterial
KW  - Genome
KW  - Gram-negative bacteria
KW  - Colistin
KW  - Microbial sensitivity tests
KW  - Antiinfecciosos
KW  - Farmacorresistencia bacteriana múltiple
KW  - Genoma
KW  - Bacterias gramnegativas
KW  - Colistina
KW  - Pruebas de sensibilidad microbiana
KW  - Medical Subject Headings::Chemicals and Drugs::Polycyclic Compounds::Macrocyclic Compounds::Peptides, Cyclic::Polymyxins::Colistin
KW  - Medical Subject Headings::Phenomena and Processes::Microbiological Phenomena::Drug Resistance, Microbial::Drug Resistance, Bacterial::Drug Resistance, Multiple, Bacterial
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Peptide Hydrolases::Endopeptidases
KW  - Medical Subject Headings::Organisms::Bacteria::Gram-Negative Bacteria
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Clinical Laboratory Techniques::Microbiological Techniques::Microbial Sensitivity Tests
KW  - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome
KW  - Medical Subject Headings::Organisms::Viruses::Bacteriophages
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals
TI  - In vitro and in vivo efficacy of combinations of colistin and different endolysins against clinical strains of multi-drug resistant pathogens
TY  - research article
ER  -