TY - JOUR AU - FrontiƱan-Rubio, Javier AU - Santiago-Mora, Raquel Maria AU - Nieva-Velasco, Consuelo Maria AU - Ferrin, Gustavo AU - Martinez-Gonzalez, Alicia AU - Gomez, Maria Victoria AU - Moreno, Maria AU - Ariza, Julia AU - Lozano, Eva AU - Arjona-Gutierrez, Jacinto AU - Gil-Agudo, Antonio AU - De la Mata, Manuel AU - Pesic, Milica AU - Peinado, Juan Ramon AU - Villalba, Jose M AU - Perez-Romasanta, Luis AU - Perez-Garcia, Victor M AU - Alcain, Francisco J AU - Duran-Prado, Mario PY - 2018 DO - 10.1016/j.radonc.2018.04.033 UR - http://hdl.handle.net/10668/12492 T2 - Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology AB - To investigate how the modulation of the oxidative balance affects cytotoxic therapies in glioblastoma, in vitro. Human glioblastoma U251 and T98 cells and normal astrocytes C8D1A were loaded with coenzyme Q10 (CoQ). Mitochondrial superoxide ion (O2-)... LA - en PB - Elsevier KW - Antioxidant capacity KW - Apoptosis KW - Glycolytic metabolism KW - Ionizing radiation KW - Reactive oxygen species KW - Ubiquinone KW - Antioxidants KW - Apoptosis KW - Brain neoplasms KW - DNA damage KW - Dacarbazine KW - Glioblastoma KW - Humans KW - Hydrogen peroxide KW - Mitochondria KW - Oxidative stress KW - Oxygen consumption KW - Radiation tolerance KW - Reactive oxygen species KW - Temozolomide KW - Tumor cells, cultured KW - Ubiquinone TI - Regulation of the oxidative balance with coenzyme Q10 sensitizes human glioblastoma cells to radiation and temozolomide. TY - research article VL - 128 ER -