RT Journal Article
T1 Effects of 12-week Aerobic Exercise on Arterial Stiffness, Inflammation, and Cardiorespiratory Fitness in Women with Systemic LUPUS Erythematosus: Non-Randomized Controlled Trial.
A1 Soriano-Maldonado, Alberto
A1 Morillas-de-Laguno, Pablo
A1 Sabio, José Mario
A1 Gavilán-Carrera, Blanca
A1 Rosales-Castillo, Antonio
A1 Montalbán-Méndez, Cristina
A1 Sáez-Urán, Luis Manuel
A1 Callejas-Rubio, José Luis
A1 Vargas-Hitos, José Antonio
K1 aerobic fitness
K1 atherosclerosis
K1 autoimmune diseases
K1 exercise
K1 inflammatory disease
K1 lupus
K1 physical fitness
K1 physical function
K1 pulse wave velocity
K1 vascular health
AB This study assessed the effect of 12-week aerobic exercise on arterial stiffness (primary outcome), inflammation, oxidative stress, and cardiorespiratory fitness (secondary outcomes) in women with systemic lupus erythematosus (SLE). In a non-randomized clinical trial, 58 women with SLE were assigned to either aerobic exercise (n = 26) or usual care (n = 32). The intervention comprised 12 weeks of aerobic exercise (2 sessions × 75 min/week) between 40⁻75% of the individual's heart rate reserve. At baseline and at week 12, arterial stiffness was assessed through pulse wave velocity (PWV), inflammatory (i.e., high-sensitivity C-reactive protein [hsCRP], tumor necrosis factor alpha [TFN-α], and inteleukin 6 [IL-6]) and oxidative stress (i.e., myeloperoxidase [MPO]) markers were obtained from blood samples, and cardiorespiratory fitness was assessed (Bruce test). There were no between-group differences in the changes in arterial stiffness (median PWV difference -0.034, 95% CI -0.42 to 0.36 m/s; p = 0.860) or hsCRP, TNF-α, IL-6, and MPO (all p > 0.05) at week 12. In comparison to the control group, the exercise group significantly increased cardiorespiratory fitness (median difference 2.26 minutes, 95% CI 0.98 to 3.55; p = 0.001). These results suggest that 12 weeks of progressive treadmill aerobic exercise increases cardiorespiratory fitness without exacerbating arterial stiffness, inflammation, or oxidative stress in women with SLE.
SN 2077-0383
YR 2018
FD 2018-11-24
LK http://hdl.handle.net/10668/13238
UL http://hdl.handle.net/10668/13238
LA en
DS RISalud
RD Apr 8, 2025