RT Journal Article
T1 Impact of Neuromyelitis Optica Spectrum Disorder on Quality of Life from the Patients' Perspective: An Observational Cross-Sectional Study.
A1 Meca-Lallana, José E
A1 Gómez-Ballesteros, Rocío
A1 Pérez-Miralles, Francisco
A1 Forero, Lucía
A1 Sepúlveda, María
A1 Calles, Carmen
A1 Martínez-Ginés, María L
A1 González-Suárez, Inés
A1 Boyero, Sabas
A1 Romero-Pinel, Lucía
A1 Sempere, Ángel P
A1 Meca-Lallana, Virginia
A1 Querol, Luis
A1 Costa-Frossard, Lucienne
A1 Prefasi, Daniel
A1 Maurino, Jorge
K1 Depression
K1 Fatigue
K1 Health-related quality of life
K1 Neuromyelitis optica spectrum disorder
K1 Patient-reported outcomes
AB Neuromyelitis optica spectrum disorder (NMOSD) is associated with a reduced health-related quality of life (HRQoL). The purpose of this study was to describe the impact of NMOSD on HRQoL from the patients' perspective and its relationship with other disease factors. An observational, cross-sectional study was conducted at 13 neuroimmunology clinics in Spain. Patients with NMOSD diagnosis (2015 Wingerchuk criteria) were included. The 29-item Multiple Sclerosis Impact Scale (MSIS-29) was used to assess the HRQoL. Different questionnaires were used to measure symptom severity, stigma, mood disorders, pain, fatigue, and difficulties in the workplace. Factors that impact HRQoL were identified by Spearman's correlation and multivariate linear regression analysis. Seventy-one patients were included (mean age 47.4 ± 14.9 years, 80.3% female, mean time since disease onset 9.9 ± 8.1 years). The median Expanded Disability Status Scale score was 3.0 (1.5-4.5). The mean (± SD) physical and psychological MSIS-29 sub-scores were 41.9 ± 16.8 and 20.9 ± 8.3, respectively. Fatigue and body pain were the most prevalent symptoms. Depressive symptoms were found in 44.3% (n = 31) of patients. The physical MSIS-29 dimension showed the highest correlation with symptom severity (ρ = 0.85584, p  Fatigue, pain, and depressive symptoms are frequent problems among patients with NMOSD, impacting on their quality of life. Assessment of patient-oriented outcomes may be useful to achieve a holistic approach, allowing early specific interventions.
SN 2193-8253
YR 2022
FD 2022-05-06
LK http://hdl.handle.net/10668/21485
UL http://hdl.handle.net/10668/21485
LA en
DS RISalud
RD Apr 6, 2025