RT Journal Article
T1 Improved Tear Film Stability in Patients with Dry Eye After Hyaluronic Acid and Galactoxyloglucan Use.
A1 Molina-Solana, Pedro
A1 Domínguez-Serrano, Francisco de Borja
A1 Garrido-Hermosilla, Antonio Manuel
A1 Montero-Iruzubieta, Jesús
A1 Fernández-Palacín, Ana
A1 Rodríguez-de-la-Rúa-Franch, Enrique
A1 Caro-Magdaleno, Manuel
K1 artificial tears
K1 dry eye
K1 non-invasive Keratograph break-up time
K1 Keratograph
K1 Ocular Surface Disease Index
AB Artificial tears only provide transient relief for dry eye. To the best of our knowledge, this is the first study to objectively compare treatment with artificial tears with Keratograph 5M, which allows accurate and objective investigation of dry eye and artificial tear treatment. We aimed to evaluate whether a preservative-free combination of 0.4% hyaluronic acid and 0.2% galactoxyloglucan can improve dry eye using the new topographer, Keratograph 5M. This prospective longitudinal, single-arm interventional cohort study was performed at a tertiary referral center and involved 20 patients with dry eye (40 eyes). Preservative-free artificial tears were administered every 3 h. The participants underwent clinical and instrumental evaluations at baseline, 15, 30, 60, 90 and 120 min after instillation and 1 week and 1 month after treatment. Baseline values were considered as the controls. All patients were assessed with Keratograph 5M for non-invasive Keratograph first break-up time and non-invasive Keratograph average break-up time, conjunctival hyperemia, and tear meniscus height. Ocular surface staining with fluorescein was evaluated using the slit-lamp and fluorescein break-up time examinations, and the Ocular Surface Disease Index score was recorded for each patient. The signs and symptoms improved after 1 month of preservative-free 0.4% hyaluronic acid and 0.2% galactoxyloglucan treatment. There was a significant increase in the non-invasive Keratograph first break-up time and non-invasive Keratograph average break-up time at 15, 30, 60, and 90 min, and 1 week and 1 month (P  A combination of 0.4% hyaluronic acid and 0.2% galactoxyloglucan artificial tears seems effective for treating dry eye. Keratograph 5M can objectively detect these changes during the follow-up period.
SN 1177-5467
YR 2020
FD 2020-04-28
LK https://hdl.handle.net/10668/27696
UL https://hdl.handle.net/10668/27696
LA en
DS RISalud
RD Apr 17, 2025