TY - JOUR AU - Lafuente-Barquero, Juan AU - Luke-Glaser, Sarah AU - Graf, Marco AU - Silva, Sonia AU - Gómez-González, Belén AU - Lockhart, Arianna AU - Lisby, Michael AU - Aguilera, Andrés AU - Luke, Brian PY - 2017 DO - 10.1371/journal.pgen.1007136 UR - http://hdl.handle.net/10668/11955 T2 - PLoS genetics AB - RNA-DNA hybrids are naturally occurring obstacles that must be overcome by the DNA replication machinery. In the absence of RNase H enzymes, RNA-DNA hybrids accumulate, resulting in replication stress, DNA damage and compromised genomic integrity. We... LA - en KW - Cell Cycle Proteins KW - DEAD-box RNA Helicases KW - DNA KW - DNA Damage KW - DNA Repair KW - DNA Replication KW - RNA Helicases KW - RNA, Fungal KW - Ribonuclease H KW - Saccharomyces cerevisiae KW - Saccharomyces cerevisiae Proteins TI - The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damage. TY - research article VL - 13 ER -