RT Journal Article
T1 Endocrine disrupting potential of replacement flame retardants - Review of current knowledge for nuclear receptors associated with reproductive outcomes
A1 Bajard, Lola
A1 Negi, Chander K.
A1 Mustieles, Vicente
A1 Melymuk, Lisa
A1 Jomini, Stéphane
A1 Barthelemy-Berneron, Johanna
A1 Fernandez, Mariana F.
A1 Blaha, Ludek
K1 Endocrine disruption
K1 Nuclear receptors
K1 Steroid hormones
K1 Flame retardants
K1 Emerging contaminants
K1 ToxCast
K1 Disruptores endocrinos
K1 Receptores citoplasmáticos y nucleares
K1 Esteroides
K1 Retardadores de llama
K1 Toxicidad
K1 Salud pública
K1 Hormonas
AB Background and aim: Endocrine disrupting chemicals (EDCs) constitute a major public health concern because they can induce a large spectrum of adverse effects by interfering with the hormonal system. Rapid identification of potential EDCs using in vitro screenings is therefore critical, particularly for chemicals of emerging concerns such as replacement flame retardants (FRs). The review aimed at identifying (1) data gaps and research needs regarding endocrine disrupting (ED) properties of replacement FRs and (2) potential EDCs among these emerging chemicals. Methods: A systematic search was performed from open literature and ToxCast/Tox21 programs, and results from in vitro tests on the activities of 52 replacement FRs towards five hormone nuclear receptors (NRs) associated with reproductive outcomes (estrogen, androgen, glucocorticoid, progesterone, and aryl hydrocarbon receptors) were compiled and organized into tables. Findings were complemented with information from structure-based in silico model predictions and in vivo information when relevant. Results: For the majority of the 52 replacement FRs, experimental in vitro data on activities towards these five NRs were either incomplete (15 FRs) or not found (24 FRs). Within the replacement FRs for which effect data were found, some appeared as candidate EDCs, such as triphenyl phosphate (TPhP) and tris(1,3-dichloropropyl) phosphate (TDCIPP). The search also revealed shared ED profiles. For example, anti-androgenic activity was reported for 19 FRs and predicted for another 21 FRs. Discussion: This comprehensive review points to critical gaps in knowledge on ED potential for many replacement FRs, including chemicals to which the general population is likely exposed. Although this review does not cover all possible characteristics of ED, it allowed the identification of potential EDCs associated with reproductive outcomes, calling for deeper evaluation and possibly future regulation of these chemicals. By identifying shared ED profiles, this work also raises concerns for mixture effects since the population is co-exposed to several FRs and other chemicals.
PB Elsevier
SN 0160-4120
YR 2021
FD 2021-04-10
LK http://hdl.handle.net/10668/4515
UL http://hdl.handle.net/10668/4515
LA en
NO Bajard L, Negi CK, Mustieles V, Melymuk L, Jomini S, Barthelemy-Berneron J, et al. Endocrine disrupting potential of replacement flame retardants - Review of current knowledge for nuclear receptors associated with reproductive outcomes. Environ Int. 2021 Aug;153:106550
DS RISalud
RD Apr 9, 2025