RT Journal Article
T1 Plasma concentrations of persistent organic pollutants and pancreatic cancer risk
A1 Porta, Miquel
A1 Gasull, Magda
A1 Pumarega, Jose
A1 Kiviranta, Hannu
A1 Rantakokko, Panu
A1 Raaschou-Nielsen, Ole
A1 Bergdahl, Ingvar A.
A1 Manning Sandanger, Torkjel
A1 Agudo, Antoni
A1 Rylander, Charlotta
A1 Nost, Therese Haugdahl
A1 Donat-Vargas, Carolina
A1 Aune, Dagfinn
A1 Heath, Alicia K.
A1 Cirera, Lluis
A1 Goni-Irigoyen, Fernando
A1 Alguacil, Juan
A1 Gimenez-Robert, Alex
A1 Tjonneland, Anne
A1 Sund, Malin
A1 Overvad, Kim
A1 Romana Mancini, Francesca
A1 Rebours, Vinciane
A1 Boutron-Ruault, Marie-Christine
A1 Kaaks, Rudolf
A1 Schulze, Matthias B.
A1 Trichopoulou, Antonia
A1 Palli, Domenico
A1 Grioni, Sara
A1 Tumino, Rosario
A1 Naccarati, Alessio
A1 Panico, Salvatore
A1 Vermeulen, Roel
A1 Quiros, J. Ramon
A1 Rodriguez-Barranco, Miguel
A1 Colorado-Yohar, Sandra M.
A1 Chirlaque, Maria-Dolores
A1 Ardanaz, Eva
A1 Wareham, Nick
A1 Key, Tim
A1 Johansson, Mattias
A1 Murphy, Neil
A1 Ferrari, Pietro
A1 Huybrechts, Inge
A1 Chajes, Veronique
A1 Alberto Gonzalez, Carlos
A1 Bueno-de-Mesquita, Bas
A1 Gunter, Marc
A1 Weiderpass, Elisabete
A1 Riboli, Elio
A1 Duell, Eric J.
A1 Katzke, Verena
A1 Vineis, Paolo
K1 Pancreatic cancer
K1 persistent organic pollutants
K1 biomarkers
K1 environmental health
K1 methods
K1 Organochlorine compounds
K1 Chemicals
K1 Exposure
AB Background Findings and limitations of previous studies on persistent organic pollutants (POPs) and pancreatic cancer risk support conducting further research in prospective cohorts. Methods We conducted a prospective case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Participants were 513 pancreatic cancer cases and 1020 matched controls. Concentrations of 22 POPs were measured in plasma collected at baseline. Results Some associations were observed at higher concentrations of p, p'-DDT, trans-nonachlor, beta-hexachlorocyclohexane and the sum of six organochlorine pesticides and of 16 POPs. The odds ratio (OR) for the upper quartile of trans-nonachlor was 1.55 (95% confidence interval 1.06-2.26; P for trend = 0.025). Associations were stronger in the groups predefined as most valid (participants having fasted >6 h, with microscopic diagnostic confirmation, normal weight, and never smokers), and as most relevant (follow-up >= 10 years). Among participants having fasted >6 h, the ORs were relevant for 10 of 11 exposures. Higher ORs were also observed among cases with microscopic confirmation than in cases with a clinical diagnosis, and among normal-weight participants than in the rest of participants. Among participants with a follow-up >= 10 years, estimates were higher than in participants with a shorter follow-up (for trans-nonachlor: OR = 2.14, 1.01 to 4.53, P for trend = 0.035). Overall, trans-nonachlor, three PCBs and the two sums of POPs were the exposures most clearly associated with pancreatic cancer risk. Conclusions Individually or in combination, most of the 22 POPs analysed did not or only moderately increased the risk of pancreatic cancer.
PB Oxford univ press
SN 0300-5771
YR 2021
FD 2021-07-14
LK https://hdl.handle.net/10668/24659
UL https://hdl.handle.net/10668/24659
LA en
DS RISalud
RD Apr 12, 2025