TY  - JOUR
AU  - Diaz-Ganete, Antonia
AU  - Quiroga-de-Castro, Aranzazu
AU  - Mateos, Rosa M.
AU  - Medina, Francisco
AU  - Segundo, Carmen
AU  - Lechuga-Sancho, Alfonso M.
PY  - 2021
DO  - 10.3390/ijms22052559
SN  - 1661-6596
UR  - http://hdl.handle.net/10668/4497
T2  - International Journal of Molecular Sciences
AB  - Basic research on types 1 and 2 diabetes mellitus require early stage studies using beta cells or cell lines, ideally of human origin and with preserved insulin secretion in response to glucose. The 1.1E7 cells are a hybrid cell line resulting from...
LA  - en
PB  - MDPI
KW  - Apoptosis
KW  - Beta cell
KW  - Cytokines
KW  - Cytotoxicity
KW  - Diabetes
KW  - Glucotoxicity
KW  - Lipotoxicity
KW  - Mechanism
KW  - Células secretoras de insulina
KW  - Citocinas
KW  - Citotoxicidad inmunológica
KW  - Glucosa
KW  - Lípidos
KW  - Toxicidad
KW  - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death::Apoptosis
KW  - Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line
KW  - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Survival
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines
KW  - Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression
KW  - Medical Subject Headings::Chemicals and Drugs::Carbohydrates::Monosaccharides::Hexoses::Glucose
KW  - Medical Subject Headings::Anatomy::Cells::Endocrine Cells::Enteroendocrine Cells::Insulin-Secreting Cells
KW  - Medical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acids::Palmitic Acids::Palmitates
KW  - Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, Messenger
TI  - Toxicity Induced by Cytokines, Glucose, and Lipids Increase Apoptosis and Hamper Insulin Secretion in the 1.1E7 Beta Cell-Line
TY  - research article
ER  -