RT Journal Article
T1 Magnesium supplementation reduces inflammation in rats with induced chronic kidney disease.
A1 Lopez-Baltanas, Rodrigo
A1 Encarnacion Rodriguez-Ortiz, Maria
A1 Canalejo, Antonio
A1 Diaz-Tocados, Juan M
A1 Herencia, Carmen
A1 Leiva-Cepas, Fernando
A1 Torres-Peña, Jose D
A1 Ortiz-Morales, Ana
A1 Muñoz-Castañeda, Juan Rafael
A1 Rodriguez, Mariano
A1 Almaden, Yolanda
K1 Chronic kidney disease
K1 Inflammation
K1 Magnesium
K1 Phosphate
K1 Uraemia
K1 Vascular smooth muscle cells
AB Inflammation is a common feature in chronic kidney disease (CKD) that appears specifically associated with cardiovascular derangements in CKD patients. Observational studies have revealed a link between low Mg levels and inflammation. In this study, we hypothesize that Mg might have a modulatory effect on the inflammation induced under the uraemic milieu. In vivo studies were performed in a 5/6 nephrectomized rat model of CKD. Furthermore, a possible direct effect of Mg was addressed through in vitro studies with vascular smooth muscle cells (VSMCs). Uraemic rats fed a normal (0.1%) Mg diet showed a systemic inflammatory response evidenced by the elevation in plasma of the pro-inflammatory cytokines TNF-α, IL-1β and IL-6, and GPx activity, a marker of oxidative stress. Importantly, an increased expression of these cytokines in the aortic tissue was also observed. In contrast, a dietary Mg supplementation (0.6%) greatly prevented the oxidative stress and the pro-inflammatory response. In vitro, in VSMCs cultured in a pro-inflammatory high phosphate medium, incubation with Mg 1.6 mM inhibited the increase in the production of ROS, the rise in the expression of TNF-α, IL-1β, IL-6 and IL-8 and the activation of NF-κB signalling that was observed in cells incubated with a normal (0.8 mM) Mg. Mg supplementation reduced inflammation associated with CKD, exerting a direct effect on vascular cells. These findings support a possible beneficial effect of Mg supplementation along the clinical management of CKD patients.
PB Wiley
YR 2021
FD 2021-03-29
LK http://hdl.handle.net/10668/17599
UL http://hdl.handle.net/10668/17599
LA en
NO López-Baltanás R, Encarnación Rodríguez-Ortiz M, Canalejo A, Díaz-Tocados JM, Herencia C, Leiva-Cepas F, et al. Magnesium supplementation reduces inflammation in rats with induced chronic kidney disease. Eur J Clin Invest. 2021 Aug;51(8):e13561
DS RISalud
RD Apr 6, 2025