RT Journal Article T1 Use of Different Food Classification Systems to Assess the Association between Ultra-Processed Food Consumption and Cardiometabolic Health in an Elderly Population with Metabolic Syndrome (PREDIMED-Plus Cohort) A1 Martinez-Perez, Celia A1 San-Cristobal, Rodrigo A1 Guallar-Castillon, Pilar A1 Martínez-González, Miguel Ángel A1 Salas-Salvadó, Jordi A1 Corella, Dolores A1 Castañer, Olga A1 Martinez, Jose Alfredo A1 Alonso-Gómez, Ángel M. A1 Wärnberg, Julia A1 Vioque, Jesús A1 Romaguera, Dora A1 López-Miranda, José A1 Estruch, Ramon A1 Tinahones, Francisco J. A1 Lapetra, José A1 Serra-Majem, Lluis A1 Bueno-Cavanillas, Aurora A1 Tur, Josep A. A1 Martín Sánchez, Vicente A1 Pintó, Xavier A1 Gaforio, José J. A1 Matía-Martín, Pilar A1 Vidal, Josep A1 Vázquez, Clotilde A1 Ros, Emilio A1 Bes-Rastrollo, Maira A1 Babio, Nancy A1 Sorlí, Jose V. A1 Lassale, Camille A1 Pérez-Sanz, Beatriz A1 Vaquero-Luna, Jessica A1 Ajejas Bazán, María Julia A1 Barceló-Iglesias, María Concepción A1 Konieczna, Jadwiga A1 Ríos, Antonio García A1 Bernal-López, María Rosa A1 Santos-Lozano, José Manuel A1 Toledo, Estefanía A1 Becerra-Tomás, Nerea A1 Portoles, Olga A1 Zomeño, María Dolores A1 Abete, Itziar A1 Moreno-Rodriguez, Anai A1 Lecea-Juarez, Oscar A1 Nishi, Stephanie K. A1 Muñoz-Martínez, Júlia A1 Ordovás, José M. A1 Daimiel, Lidia K1 Cardiometabolic risk K1 Classification systems K1 Diet K1 Food processing K1 IARC K1 IFIC K1 NOVA K1 PREDIMED-Plus K1 Ultra-processed food K1 UNC K1 Overweight K1 Mediterranean diet K1 Metabolic syndrome K1 Body mass index K1 Obesity K1 Factores de riesgo cardiometabólico K1 Clasificación K1 Dieta K1 Manipulación de alimentos K1 Alimentos ultraprocesados K1 Sobrepeso K1 Dieta mediterránea K1 Síndrome metabólico K1 Índice de masa corporal K1 Obesidad AB The association between ultra-processed food (UPF) and risk of cardiometabolic disorders is an ongoing concern. Different food processing-based classification systems have originated discrepancies in the conclusions among studies. To test whether the association between UPF consumption and cardiometabolic markers changes with the classification system, we used baseline data from 5636 participants (48.5% female and 51.5% male, mean age 65.1 ± 4.9) of the PREDIMED-Plus ("PREvention with MEDiterranean DIet") trial. Subjects presented with overweight or obesity and met at least three metabolic syndrome (MetS) criteria. Food consumption was classified using a 143-item food frequency questionnaire according to four food processing-based classifications: NOVA, International Agency for Research on Cancer (IARC), International Food Information Council (IFIC) and University of North Carolina (UNC). Mean changes in nutritional and cardiometabolic markers were assessed according to quintiles of UPF consumption for each system. The association between UPF consumption and cardiometabolic markers was assessed using linear regression analysis. The concordance of the different classifications was assessed with intra-class correlation coefficients (ICC3, overall = 0.51). The highest UPF consumption was obtained with the IARC classification (45.9%) and the lowest with NOVA (7.9%). Subjects with high UPF consumption showed a poor dietary profile. We detected a direct association between UPF consumption and BMI (p = 0.001) when using the NOVA system, and with systolic (p = 0.018) and diastolic (p = 0.042) blood pressure when using the UNC system. Food classification methodologies markedly influenced the association between UPF consumption and cardiometabolic risk markers. PB MDPI YR 2021 FD 2021-07-20 LK http://hdl.handle.net/10668/4560 UL http://hdl.handle.net/10668/4560 LA en NO Martinez-Perez C, San-Cristobal R, Guallar-Castillon P, Martínez-González MÁ, Salas-Salvadó J, Corella D, et al. Use of Different Food Classification Systems to Assess the Association between Ultra-Processed Food Consumption and Cardiometabolic Health in an Elderly Population with Metabolic Syndrome (PREDIMED-Plus Cohort). Nutrients. 2021 Jul 20;13(7):2471 DS RISalud RD Apr 17, 2025