%0 Journal Article
%A Ubiña-Aznar, Esther
%A Tapia-Ceballos, Leopoldo
%A Rosales-Zabal, José Miguel
%A Porcel-Chacón, Rocío
%A Poveda-Gómez, Francisco
%A Lozano-Calero, Carmen
%A Ortiz-Cuevas, Carmen
%A Rivas-Ruiz, Francisco
%A Sánchez Cantos, Andrés
%A Navarro Jarabo, José María
%T Insulin resistance and the metabolic syndrome are related to the severity of steatosis in the pediatric population with obesity.
%D 2017
%@ 1130-0108
%U http://hdl.handle.net/10668/11475
%X To determine the factors associated with an increased risk for severe steatosis (SS) and establish the Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) as a screening tool. A cross-sectional study was performed in obese children to assess the relationship between the metabolic syndrome (MetS) and glucose metabolism alterations (GMA) and the risk for severe steatosis. A total of 94 children (51 males) aged from six to 14 years were included. Thirteen children (14.8%) had severe steatosis (SS). The anthropometric variables associated with SS included body mass index (BMI) (SS 34.1 vs non-SS 29.7, p = 0.005), waist circumference (cm) (100 vs 92.5, p = 0.015) and hip circumference (cm) (108 vs 100, p = 0.018). The blood parameters included alanine aminotransferase (ALT) (UI/dl) (27 vs 21, p = 0.002), gamma-glutamil transpeptidase (GGT) (UI/dl) (16 vs 15, p = 0.017), fasting glycemia (mg/dl) (96 vs 88, p = 0.006), fasting insulin (UI/dl) (25 vs 15.3, p  The presence of MetS and glucose metabolism alterations are risk factors for severe steatosis. The 4.9 cut-off value for HOMA-IR may be a risk factor for severe steatosis in obese children.
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