RT Journal Article
T1 Epithelial Permeability to Ole e 1 Is More Dependent on the Functional State of the Bronchial Epithelium Than on the Activity of Der p 1 Protease Acting as an Adjuvant to the Bystander Allergen.
A1 Lopez-Rodriguez, J C
A1 Gonzalez, M
A1 Bogas, G
A1 Mayorga, C
A1 Villalba, M
A1 Batanero, E
K1 Allergen
K1 Basophils
K1 Bronchial epithelium permeability
K1 Der p 1
K1 Ole e 1
AB A dysfunctional epithelial barrier has been widely associated with allergy [1], although it is not clearly established whether this dysfunction is the cause or a consequence of the disease. Moreover, airway epithelial barrier integrity can be impaired by environmental proteases—mostly allergens—derived from a wide variety of biological sources such as mites, cockroaches, food plants, fungi, and pollens [2,3]. These allergens include cysteine proteases, which are potent adjuvants for promoting type 2 helper T-cell immune responses in the airways. Although it is well known that the cysteine protease Der p 1, a major allergen from house dust mite, exerts various effects on the airway epithelium that could contribute to allergic airway diseases [4-6], the cleavage of tight junction (TJ) proteins was the first activity described for it [5].
PB Esmon Publicidad
SN 1018-9068
YR 2020
FD 2020-09-30
LK http://hdl.handle.net/10668/16381
UL http://hdl.handle.net/10668/16381
LA en
NO López-Rodríguez JC, González M, Bogas G, Mayorga C, Villalba M, Batanero E. Epithelial Permeability to Ole e 1 Is More Dependent on the Functional State of the Bronchial Epithelium Than on the Activity of Der p 1 Protease Acting as an Adjuvant to the Bystander Allergen. J Investig Allergol Clin Immunol. 2021 Jul 26;31(4):343-346
NO This work was supported by the Spanish Government, cofunded by the European Union ERDF (SAF2014-53209 [MV], SAF2017- 86483-R [MV], and RD16/0006/0014 [MV]). JCL-R was supported by an FPU fellowship from the Spanish Ministry of Education, Culture, and Sport (FPU13/02393). CM is supported by the Nicolas Monardes Program (RC-0004-2016) from the Andalusian Regional Ministry of Health.
DS RISalud
RD Apr 4, 2025