RT Journal Article
T1 Radiation for Awakening the Dormant Immune System, a Promising Challenge to be Explored.
A1 Cruz-Merino, Luis de la
A1 Illescas-Vacas, Ana
A1 Grueso-López, Ana
A1 Barco-Sánchez, Antonio
A1 Míguez-Sánchez, Carlos
K1 CTLA-4
K1 abscopal effect
K1 immunotherapy
K1 radiotherapy effects
K1 tumor microenvironment
K1 Estructuras Celulares
K1 Citocinas
K1 Inmunoterapia
K1 Microambiente Tumoral
AB Recent advances that have been made in our understanding of cancer biology and immunology show that infiltrated immune cells and cytokines in the tumor microenvironment may play different functions that appear tightly related to clinical outcomes. Strategies aimed at interfering with the cross-talk between microenvironment tumor cells and their cellular partners have been considered for the development of new immunotherapies. These novel therapies target different cell components of the tumor microenvironment and importantly, they may be coupled and boosted with classical treatments, such as radiotherapy. In this work, we try to summarize recent data on the microenvironment impact of radiation therapy, from pre-clinical research to the clinic, while taking into account that this new knowledge will probably translate into indication and objective of radiation therapy changes in the next future.
PB Frontiers
YR 2014
FD 2014-03-14
LK http://hdl.handle.net/10668/1975
UL http://hdl.handle.net/10668/1975
LA en
NO Cruz-Merino L de la, Illescas-Vacas A, Grueso-López A, Barco-Sánchez A, Míguez-Sánchez C. Radiation for Awakening the Dormant Immune System, a Promising Challenge to be Explored. Front Immunol. 2014; 5:102
NO Journal Article; Review;
DS RISalud
RD Apr 18, 2025