TY - JOUR AU - Simón, Jorge AU - Goikoetxea-Usandizaga, Naroa AU - Serrano-Maciá, Marina AU - Fernández-Ramos, David AU - Sáenz de Urturi, Diego AU - Gruskos, Jessica J AU - Fernández-Tussy, Pablo AU - Lachiondo-Ortega, Sofía AU - González-Recio, Irene AU - Rodríguez-Agudo, Rubén AU - Gutiérrez-de-Juan, Virginia AU - Rodríguez-Iruretagoyena, Begoña AU - Varela-Rey, Marta AU - Gimenez-Mascarell, Paula AU - Mercado-Gomez, María AU - Gómez-Santos, Beatriz AU - Fernandez-Rodriguez, Carmen AU - Lopitz-Otsoa, Fernando AU - Bizkarguenaga, Maider AU - Dames, Sibylle AU - Schaeper, Ute AU - Martin, Franz AU - Sabio, Guadalupe AU - Iruzubieta, Paula AU - Crespo, Javier AU - Aspichueta, Patricia AU - Chu, Kevan H-Y AU - Buccella, Daniela AU - Martín, César AU - Delgado, Teresa Cardoso AU - Martínez-Cruz, Luis Alfonso AU - Martínez-Chantar, María Luz PY - 2021 DO - 10.1016/j.jhep.2021.01.043 UR - http://hdl.handle.net/10668/17148 T2 - Journal of hepatology AB - Perturbations of intracellular magnesium (Mg2+) homeostasis have implications for cell physiology. The cyclin M family, CNNM, perform key functions in the transport of Mg2+ across cell membranes. Herein, we aimed to elucidate the role of CNNM4 in the... LA - en KW - CNNM4 KW - Cyclin M4 KW - Endoplasmic reticulum stress KW - MTP KW - Magnesium KW - Microsomal triglyceride transfer protein KW - NASH KW - Non-alcoholic steatohepatitis KW - Therapy KW - siRNA KW - Animals KW - Biological Transport KW - Carrier Proteins KW - Cation Transport Proteins KW - Cells, Cultured KW - Disease Models, Animal KW - Drug Discovery KW - Endoplasmic Reticulum Stress KW - Gene Expression Regulation KW - Hepatocytes KW - Humans KW - Magnesium KW - Mice KW - Non-alcoholic Fatty Liver Disease TI - Magnesium accumulation upon cyclin M4 silencing activates microsomal triglyceride transfer protein improving NASH. TY - research article VL - 75 ER -